CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041628
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b 
Protein Synonyms/Alias
 Protein Iqgap1 
Gene Name
 Iqgap1 
Gene Synonyms/Alias
 Iqgap1_predicted; rCG_24856 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
687DNNSKWVKHWVKGGYacetylation[1]
806LAYLHSHKDEVVKIQacetylation[1]
955MMMINKQKGGLKALSacetylation[1]
959NKQKGGLKALSKEKRacetylation[1]
1088DDKSLNIKTDPVDIYacetylation[1]
1144NMRAVTDKFLSAIVSacetylation[1]
1230RNLGSIAKMLQHAASacetylation[1]
1353GNSNDPSKEALAKTEacetylation[1]
1487ELINDIAKDIRNQRRacetylation[1]
1528GEQVDYYKSYIKTCLacetylation[1]
1562KSKKISLKYTAARLHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1657 AA 
Protein Sequence
MSAAEEVDGL GVVRPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA KRWMEACLGE 60
DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL 120
NAMDEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE 180
EINNMKIELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAIDH RVAADTFTAL 240
KNPNAMLVNL EEALAPTYQD VLYQAKQDKM TNAKNRTENS DRERDVYEEL LTQAEIQGNV 300
NKVNTSSALA NINLALEQGC ALTLLKALQS VALGLRGLQT QNSDWYLKQL QSDLQQKRQS 360
GQTDPLQKEE VQAGVDAANG AAQQYQRRLA AVAAINAAIQ KGIAEKTVLE LMNPEAQLPQ 420
VYPFAADLYQ KELATLQQQS PEHSLTHPEL TVAVEMLSSV ALINRALESG DMNTVWKQLS 480
SSVTGLTNIE EENCQRYLDE LMKLKAQAHA ENNEFVTWND IQACVDHVNL VVHEEHERIL 540
AIGLINEALD EGDAQKTLQA LQIPAAKLEG VLPEVAQHYQ DTLIRAKREK AQETQDESAV 600
LWLDEIQGGI WQSNKDTQEA QRFALGIFAI NEAVESGDVG RTLSALRSPD VGLYGVIPEC 660
GETYQSDLAE AKKKRLAAGD NNSKWVKHWV KGGYHYYHNL ETQAGGWAEP PDFVQNSVQL 720
SREEIQSSIS GVTAAYNREQ LWLANEGLIT KLQACCRGYL VRQEFRSRMN FLKKQIPAIT 780
CIQSQWRGYK QKKAYQDRLA YLHSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII 840
KIQAFIRANK ARDDYKTLIN AEDPPMIVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI 900
RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM INKQKGGLKA 960
LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY 1020
LLLRLFQTAL QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILAPVVKEIM 1080
DDKSLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ ALSHEEVKTR LDNSIRNMRA 1140
VTDKFLSAIV SSVDKIPYGM RFIAKVLKDS LHEKFPDAAE DELLKIIGNL LYYRYMNPAI 1200
VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI INEYLSQSYQ 1260
KFRRFFQAAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH 1320
NDPIHELLDD LGEVPTIESL IGESCGNSND PSKEALAKTE VSLTLTNKFD VPGDENAEMD 1380
ARTILLNTKR LIVDVIRFQP GETLTEILET PATNEQEAEH QRAMQRRAIR DAKTPDKMKK 1440
SKPMKEDNNL SLQEKKEKIQ TGLKKLTELG TVDPKNRYQE LINDIAKDIR NQRRYRQRRK 1500
AELVKLQQTY SALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE MKGKKSKKIS 1560
LKYTAARLHE KGVLLEIEDL QANQFKNVIF EIGPTEEVGD FEVKAKFMGV QMETFMLHYQ 1620
DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL NKKFYGK 1657 
Gene Ontology
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0030529; C:ribonucleoprotein complex; IEA:Compara.
 GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
 GO:0071277; P:cellular response to calcium ion; IEA:Compara.
 GO:0035305; P:negative regulation of dephosphorylation; IEA:Compara.
 GO:0045860; P:positive regulation of protein kinase activity; IEA:Compara.
 GO:0032320; P:positive regulation of Ras GTPase activity; IEA:GOC.
 GO:0001817; P:regulation of cytokine production; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR001715; CH-domain.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR027417; P-loop_NTPase.
 IPR001936; RasGAP.
 IPR000593; RasGAP_C.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001202; WW_dom. 
Pfam
 PF00307; CH
 PF00612; IQ
 PF00616; RasGAP
 PF03836; RasGAP_C 
SMART
 SM00033; CH
 SM00015; IQ
 SM00323; RasGAP 
PROSITE
 PS50021; CH
 PS50096; IQ
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2
 PS01159; WW_DOMAIN_1 
PRINTS