UniProt Accession

 E9PQM8_HUMAN; E9PQM8 

Genbank Protein ID

 AL590133 

Genbank Nucleotide ID

  

Protein Name

 Histone-lysine N-methyltransferase SETDB1 

Protein Synonyms/Alias

  

Gene Name

 SETDB1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	KFMDAVNKKSSSQDL	ubiquitination	[1]
174	FMDAVNKKSSSQDLH	ubiquitination	[1]
349	NRPMVLLKSGQLIKT	ubiquitination	[2]
355	LKSGQLIKTEWEGTW	ubiquitination	[1, 2]
383	RILFLDDKRCEWIYR	ubiquitination	[1]
491	SRKQVAKKSTSFRPG	methylation	[3]
571	SYRAPMEKLFYLPHV	ubiquitination	[1]
598	RNEQYRGKNPLLVPL	ubiquitination	[1, 2, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 636 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 

Interpro

 IPR002999; Tudor. 

Pfam

  

SMART

 SM00333; TUDOR 

PROSITE

  

PRINTS