| Tag | Content |
|---|
| CPLM ID | CPLM-016518 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Connector enhancer of kinase suppressor of ras 3 |
Protein Synonyms/Alias | Connector enhancer of KSR 3; CNK homolog protein 3; CNK3; CNKSR family member 3; Maguin-like protein |
Gene Name | Cnksr3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 34 | VHKFEREKIDGEQLL | ubiquitination | [1] | | 418 | ETNVLPTKMRGKTPS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway. |
Sequence Annotation | DOMAIN 7 72 SAM.
DOMAIN 80 174 CRIC.
DOMAIN 211 293 PDZ.
DOMAIN 325 546 DUF1170.
MOD_RES 381 381 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 555 AA |
Protein Sequence | MEPVTKWSPK QVVDWTRGLD DCLQPYVHKF EREKIDGEQL LKISHQDLEE LGVTRIGHQE 60
LVLEAVDLLC ALNYGLETDT MKNLVLKLRA SSHNLQNYIS SRRKSPAYDG NTSRKPPNEF 120
LTSVVELIGA AKALLAWLDR APFTGITDLS VTKNKIIQLC LDLTTAVQKD CLIAEMEDKV 180
LNVVKVLNGI CDKTMRSTTD PVMSQCACLE EVHLPNVRPG EGLGMYIKST YDGLHVITGT 240
TENSPADRSQ KIHAGDEVIQ VNRQTVVGWQ LKNLVRKLRE NPTGVVLLLK KRPTGSFSFT 300
PAPLKNLRWK PPLVQTSPPP TTTQSPESTM DASLKKEKPA ILDLYIPPPP AVPYSPRDEN 360
VSFGYRGHSK SKQPLPVRKG SESPNSFLDQ ESQRRRFTIA DSDQLPGYSV ETNVLPTKMR 420
GKTPSYGKPR PLSMPADGNW MGIVDPFAKP RGNGRKGEDA LCRYFSNERI TPITEESASP 480
MYRFSRPLTE RHLVRGADYI RGSRCYINSD LHSSATIPFQ EEGSKKKSAS SSAKASSGEP 540
SLLVSWLTRL KLLTH 555 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0016020; C:membrane; IEA:InterPro. GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB. GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:UniProtKB. GO:2000651; P:positive regulation of sodium ion transmembrane transporter activity; IMP:MGI. GO:0010765; P:positive regulation of sodium ion transport; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |