CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021753
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myotilin 
Protein Synonyms/Alias
 Myofibrillar titin-like Ig domains protein; Titin immunoglobulin domain protein 
Gene Name
 Myot 
Gene Synonyms/Alias
 Ttid 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36SGFPSQTKQSSIVIQubiquitination[1]
167LERKLKCKDTLLHNGubiquitination[1]
244DQDAIQEKFYPPRFIubiquitination[1]
450IQTLPAPKQLRVRPTubiquitination[1]
472NGRGLDVKQAFNPEGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells (By similarity). 
Sequence Annotation
 DOMAIN 248 333 Ig-like C2-type 1.
 DOMAIN 347 439 Ig-like C2-type 2.
 REGION 78 149 Necessary for interaction with ACTN1 (By
 REGION 213 496 Necessary for interaction with ACTA1 (By
 REGION 213 491 Necessary for interaction with FLNC (By  
Keyword
 Actin-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Immunoglobulin domain; Membrane; Muscle protein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 496 AA 
Protein Sequence
MFNYERPKHF IQPQNPCGSR LQPPGPEVSG FPSQTKQSSI VIQPRQCTEQ RFSASSTVSS 60
HITVSSSAYP APQQLAGPNP GQKVTATYNQ SPASFLSSIL PSQPDYCNSK IPSTVDSNYQ 120
QSSVNQPVNA MSSQAANARP TPKTPDHEIQ GSKEALIQDL ERKLKCKDTL LHNGNQRLTY 180
EEKMARRLLG PQNAAAVFQA QNSDVQDSPQ HNPEQARLHV PTSQVRSRSS SRAEANDQDA 240
IQEKFYPPRF IQVPENMSIE EGRFCRMDFK VSGLPAPDVS WYLNGRPVQS DELHKMIVSE 300
KGFHSLIFEV VRASDAGPYA CVARNRAGEA TFTVQLDVLA KEHKRAPMFI FKPQSKKVFE 360
GETVKLECQI SAIPPPKLFW KRNNEMVQFN TDRISLYHDN AGRVTLLIKD VNKKDAGWYT 420
VSAVNEAGVT TCNTRLDVTA RPIQTLPAPK QLRVRPTFSK YLALNGRGLD VKQAFNPEGE 480
FQRLAAQSGL YESEEL 496 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0051393; F:alpha-actinin binding; ISO:MGI. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF07679; I-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS