CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006246
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein PDC2 
Protein Synonyms/Alias
  
Gene Name
 PDC2 
Gene Synonyms/Alias
 YDR081C; D4451 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
252MLGTKMAKKFDISYHubiquitination[1]
253LGTKMAKKFDISYHSubiquitination[1]
565NDNDSSVKYLQQNTVacetylation[2]
622NDPYNTMKQPGPLDYubiquitination[1]
Reference
 [1] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Essential for the synthesis of pyruvate decarboxylase. May be important for a high basal level of PDC gene expression or play a positive role in the autoregulation control of PDC1 and PDC5. 
Sequence Annotation
 DOMAIN 63 138 HTH CENPB-type.  
Keyword
 Complete proteome; DNA-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 925 AA 
Protein Sequence
MLSIQQRYNI CLMAERHPKW TQLELAKWAY ETFQLPKIPS QGTISRLLAR KSTYMNCKEH 60
EKDANRLRKP NNLLVRKILQ EWISQSLWNG IPITSPIIQD TAQAVWHRIP AEHREGNGSF 120
SYKWISNFLS KMDVNISVLD EELPKTPKVW TFEERDVLKA YFSKIPPKDL FTLDEAFLSY 180
NLPLDYAQYE ASSIQRRIEV ATVMLCSNLD GSEKLKPVVV GKYDSYKSFR NYFPNEPNDP 240
VSQSMLGTKM AKKFDISYHS NRKAWLTSNL FHNWLVRWDK RLVAVNRKIW IVLDDSCCHR 300
IINLRLQNIK LVYTSSNSKF LPFNWGVWDE FKTRYRIQQY QALIDLQNRI SKNIQNKNKS 360
ERNECIPNGK KCLISFEQSQ LTMSNAFKFI KKAWDDIPVD AIKANWKSSG LLPPEMIHLN 420
ENVSMAFKKN EVLESVLNRL CDEYYCVKKW EYEMLLDLNI ENKNTNFLST EELVESAIVE 480
PCEPDFDTAP KGNEVHDDNF DVSVFANEDD NNQNHLSMSQ ASHNPDYNSN HSNNAIENTN 540
NRGSNNNNNN NGSSNNINDN DSSVKYLQQN TVDNSTKTGN PGQPNISSME SQRNSSTTDL 600
VVDGNYDVNF NGLLNDPYNT MKQPGPLDYN VSTLIDKPNL FLSPDLDLST VGVDMQLPSS 660
EYFSEVFSSA IRNNEKAASD QNKSTDELPS STAMANSNSI TTALLESRNQ AQPFDVPHMN 720
GLLSDTSKSG HSVNSSNAIS QNSLNNFQHN SASVAEASSP SITPSPVAIN STGAPARSII 780
SAPIDSNSSA SSPSALEHLE GAVSGMSPSS TTILSNLQTN INIAKSLSTI MKHAESNEIS 840
LTKETINELN FNYLTLLKRI KKTRKQLNSE SIKINSKNAQ DHLETLLSGA AAAAATSANN 900
LDLPTGGSNL PDSNNLHLPG NTGFF 925 
Gene Ontology
 GO:0005634; C:nucleus; IC:SGD.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD.
 GO:2001172; P:positive regulation of glucose catabolic process to ethanol; IMP:SGD.
 GO:0090180; P:positive regulation of thiamine biosynthetic process; IMP:SGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:SGD. 
Interpro
 IPR004875; DDE_SF_endonuclease_CENPB-like.
 IPR009057; Homeodomain-like.
 IPR006600; HTH_CenpB_DNA-bd_dom. 
Pfam
 PF03184; DDE_1
 PF03221; HTH_Tnp_Tc5 
SMART
 SM00674; CENPB 
PROSITE
 PS51253; HTH_CENPB 
PRINTS