UniProt Accession

 CTBP2_HUMAN; P56545; A8K2X5; D3DRF5; O43449; Q5SQP7; Q69YI3; Q86SV0; Q9H2T8 

Genbank Protein ID

 AF016507; AF222711; BT007012; AK290390; AL833398; AL596261; AL731571; AL731571; AL596261; AL731571; CH471066; CH471066; CH471066; BC002486; BC047018; BC052276; BC072020 

Genbank Nucleotide ID

 AAC39603.1; AAG45951.1; AAP35658.1; BAF83079.1; CAH10590.1; CAH72472.1; CAH72472.1; CAI16100.1; CAI16100.1; CAI16102.1; EAW49247.1; EAW49250.1; EAW49249.1; AAH02486.1; AAH47018.1; AAH52276.1; AAH72020.1 

Protein Name

 C-terminal-binding protein 2 

Protein Synonyms/Alias

 CtBP2 

Gene Name

 CTBP2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MALVDKHKVKRQR	acetylation	[1]
8	MALVDKHKVKRQRLD	acetylation	[1]
10	LVDKHKVKRQRLDRI	acetylation	[1]
279	RGGLVDEKALAQALK	ubiquitination	[2]
286	KALAQALKEGRIRGA	ubiquitination	[2]

Reference

 [1] Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2.
 Zhao LJ, Subramanian T, Zhou Y, Chinnadurai G.
 J Biol Chem. 2006 Feb 17;281(7):4183-9. [PMID: 16356938]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). 

Sequence Annotation

 NP_BIND 186 191 NAD.
 NP_BIND 243 249 NAD.
 NP_BIND 270 272 NAD.
 NP_BIND 321 324 NAD.
 ACT_SITE 272 272 By similarity.
 ACT_SITE 301 301 By similarity.
 ACT_SITE 321 321 Proton donor (By similarity).
 BINDING 106 106 NAD (By similarity).
 BINDING 210 210 NAD.
 BINDING 296 296 NAD.  

Keyword

 3D-structure; Alternative splicing; Cell junction; Complete proteome; Differentiation; Direct protein sequencing; NAD; Nucleus; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Synapse; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0017053; C:transcriptional repressor complex; ISS:UniProtKB.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0019079; P:viral genome replication; TAS:ProtInc.
 GO:0050872; P:white fat cell differentiation; ISS:UniProtKB. 

Interpro

 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 

SMART

  

PROSITE

 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 

PRINTS