CPLM-008237

Genbank Nucleotide ID

Double-strand break repair protein MRE11A

Protein Synonyms/Alias

Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A

Homo sapiens (Human)

Position	Peptide	Type	References
384	SVLRFSQKFVDRVAN	ubiquitination	[1]
393	VDRVANPKDIIHFFR	ubiquitination	[1]
416	GEEINFGKLITKPSE	ubiquitination	[1]
434	LRVEDLVKQYFQTAE	ubiquitination	[1]
442	QYFQTAEKNVQLSLL	ubiquitination	[1]
475	DAIEELVKYQLEKTQ	ubiquitination	[1]
480	LVKYQLEKTQRFLKE	acetylation	[2]
673	WSSTSSSKIMSQSQV	ubiquitination	[1]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

ACT_SITE 129 129 Proton donor (By similarity).
MOD_RES 2 2 N-acetylserine.
MOD_RES 649 649 Phosphoserine.
MOD_RES 688 688 Phosphoserine.
MOD_RES 689 689 Phosphoserine.
MOD_RES 701 701 Phosphoserine.

3D-structure; Acetylation; Alternative splicing; Ciliopathy; Complete proteome; Disease mutation; DNA damage; DNA repair; Endonuclease; Exonuclease; Hydrolase; Manganese; Meiosis; Nuclease; Nucleus; Phosphoprotein; Polymorphism; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030870; C:Mre11 complex; NAS:BHF-UCL.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0008408; F:3'-5' exonuclease activity; TAS:ProtInc.
GO:0003690; F:double-stranded DNA binding; TAS:ProtInc.
GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; TAS:ProtInc.
GO:0000075; P:cell cycle checkpoint; IEA:Compara.
GO:0008283; P:cell proliferation; IEA:Compara.
GO:0032508; P:DNA duplex unwinding; IMP:BHF-UCL.
GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.
GO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:ProtInc.
GO:0032876; P:negative regulation of DNA endoreduplication; IMP:BHF-UCL.
GO:0033674; P:positive regulation of kinase activity; IDA:BHF-UCL.
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:BHF-UCL.
GO:0007131; P:reciprocal meiotic recombination; TAS:ProtInc.
GO:0000019; P:regulation of mitotic recombination; TAS:ProtInc.
GO:0007062; P:sister chromatid cohesion; IMP:BHF-UCL.
GO:0007129; P:synapsis; IEA:Compara.
GO:0007004; P:telomere maintenance via telomerase; TAS:ProtInc.

IPR003701; DNA_repair_Mre11.
IPR004843; Metallo_PEstase_dom.
IPR007281; Mre11_DNA-bd.

PF00149; Metallophos
PF04152; Mre11_DNA_bind