UniProt Accession

 NQO1_MOUSE; Q64669 

Genbank Protein ID

 U12961; S75951 

Genbank Nucleotide ID

 AAA80184.1; AAB32718.1 

Protein Name

 NAD(P)H dehydrogenase [quinone] 1 

Protein Synonyms/Alias

 Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; Quinone reductase 1; QR1 

Gene Name

 Nqo1 

Gene Synonyms/Alias

 Dia4; Nmo1; Nmor1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
77	SESSLAYKEGRLSPD	acetylation	[1]
77	SESSLAYKEGRLSPD	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis (By similarity). 

Sequence Annotation

 NP_BIND 18 19 FAD.
 NP_BIND 104 107 FAD.
 NP_BIND 148 151 FAD.
 REGION 126 128 Substrate binding (By similarity).
 BINDING 12 12 FAD.
 BINDING 67 67 FAD.
 BINDING 156 156 FAD.
 BINDING 201 201 FAD.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; FAD; Flavoprotein; NAD; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity; IDA:MGI.
 GO:0004784; F:superoxide dismutase activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0043086; P:negative regulation of catalytic activity; IDA:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IMP:MGI.
 GO:0006801; P:superoxide metabolic process; IEA:Compara. 

Interpro

 IPR003680; Flavodoxin_fold. 

Pfam

 PF02525; Flavodoxin_2 

SMART

  

PROSITE

  

PRINTS