Tag | Content |
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CPLM ID | CPLM-008305 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Max-interacting protein 1 |
Protein Synonyms/Alias | Max interactor 1; Class C basic helix-loop-helix protein 11; bHLHc11 |
Gene Name | MXI1 |
Gene Synonyms/Alias | BHLHC11 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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158 | RLCLERLKVLIPLGP | ubiquitination | [1] | 192 | KLEEAERKSQHQLEN | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. |
Sequence Annotation | DOMAIN 67 119 bHLH. |
Keyword | Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Nucleus; Proto-oncogene; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 228 AA |
Protein Sequence | MGKRGRPRKE ARCEGAGLAP AAPPAVPPAV AAPQPPALPE DPAGAKPRCP FSDIFNTSEN 60 SMEKHINTFL QNVQILLEAA SYLEQIEKEN KKCEHGYASS FPSMPSPRLQ HSKPPRRLSR 120 AQKHSSGSSN TSTANRSTHN ELEKNRRAHL RLCLERLKVL IPLGPDCTRH TTLGLLNKAK 180 AHIKKLEEAE RKSQHQLENL EREQRFLKWR LEQLQGPQEM ERIRMDSIGS TISSDRSDSE 240 REEIEVDVES TEFSHGEVDN ISTTSISDID DHSSLPSIGS DEGYSSASVK LSFTS 295 |
Gene Ontology | GO:0005634; C:nucleus; TAS:ProtInc. GO:0003677; F:DNA binding; TAS:ProtInc. GO:0003714; F:transcription corepressor activity; TAS:ProtInc. GO:0042994; P:cytoplasmic sequestering of transcription factor; TAS:ProtInc. GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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