UniProt Accession

 RA1L2_HUMAN; Q32P51; Q5TBS2 

Genbank Protein ID

 AK123159; AL137058; CH471124; BC108266 

Genbank Nucleotide ID

 CAI16736.1; EAW52041.1; AAI08267.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A1-like 2 

Protein Synonyms/Alias

 hnRNP A1-like 2; hnRNP core protein A1-like 2 

Gene Name

 HNRNPA1L2 

Gene Synonyms/Alias

 HNRNPA1L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	KEPEQLRKLFIGGLS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (By similarity). 

Sequence Annotation

 DOMAIN 14 97 RRM 1.
 DOMAIN 105 184 RRM 2.
 REGION 4 94 Globular A domain.
 REGION 95 185 Globular B domain.
 REGION 218 240 RNA-binding RGG-box.
 REGION 268 305 Nuclear targeting sequence (By
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 6 6 Phosphoserine (By similarity).
 MOD_RES 194 194 Asymmetric dimethylarginine (By
 MOD_RES 313 313 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Methylation; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 320 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR021662; HnRNPA1.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF11627; HnRNPA1
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS