UniProt Accession

 YPT7_YEAST; P32939; D6VZH4 

Genbank Protein ID

 X68144; D64114; Z48613; BK006946 

Genbank Nucleotide ID

 CAA48244.1; BAA10973.1; CAA88515.1; DAA09898.1 

Protein Name

 GTP-binding protein YPT7 

Protein Synonyms/Alias

  

Gene Name

 YPT7 

Gene Synonyms/Alias

 VAM4; YML001W; YM8270.02 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
21	LGDSGVGKTSLMHRY	ubiquitination	[1]
32	MHRYVNDKYSQQYKA	acetylation	[2]
32	MHRYVNDKYSQQYKA	ubiquitination	[1]
56	EVTVDGDKVATMQVW	ubiquitination	[1]
140	SKKIVSEKSAQELAK	ubiquitination	[1]
147	KSAQELAKSLGDIPL	ubiquitination	[1, 3]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process. 

Sequence Annotation

 NP_BIND 15 22 GTP (By similarity).
 NP_BIND 64 68 GTP (By similarity).
 NP_BIND 126 129 GTP (By similarity).
 MOTIF 37 45 Effector region (Probable).
 MOD_RES 208 208 Cysteine methyl ester (By similarity).
 LIPID 206 206 S-geranylgeranyl cysteine (By
 LIPID 208 208 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Complete proteome; GTP-binding; Lipoprotein; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport; Vacuole. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0006896; P:Golgi to vacuole transport; TAS:SGD.
 GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD.
 GO:0072665; P:protein localization to vacuole; IMP:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032889; P:regulation of vacuole fusion, non-autophagic; IMP:SGD.
 GO:0042147; P:retrograde transport, endosome to Golgi; IPI:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0000011; P:vacuole inheritance; IDA:SGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.