UniProt Accession

 ABT1_HUMAN; Q9ULW3 

Genbank Protein ID

 AB027258; AL513548; BC048812; BC066313 

Genbank Nucleotide ID

 BAA86886.1; CAC40824.1; AAH48812.1; AAH66313.1 

Protein Name

 Activator of basal transcription 1 

Protein Synonyms/Alias

 hABT1; Basal transcriptional activator 

Gene Name

 ABT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
146	RYDLWNLKYLHRFTW	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). 

Sequence Annotation

 DOMAIN 46 142 RRM.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Coiled coil; Complete proteome; DNA-binding; Nucleus; Reference proteome; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 272 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0021522; P:spinal cord motor neuron differentiation; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait. 

Pfam

  

SMART

  

PROSITE

 PS50102; RRM 

PRINTS