UniProt Accession

 NDC1_HUMAN; Q9BTX1; Q8NB76; Q9H9T6; Q9NSG3; Q9NSG4; Q9NVZ7 

Genbank Protein ID

 DQ141696; AK001269; AK022618; AK091439; AL354612; AL354613; AL049745; BC003082 

Genbank Nucleotide ID

 AAZ73087.1; BAA91592.1; BAB14135.1; BAC03665.1; CAB89725.1; CAB89726.1; CAI22180.1; AAH03082.1 

Protein Name

 Nucleoporin NDC1 

Protein Synonyms/Alias

 hNDC1; Transmembrane protein 48 

Gene Name

 NDC1 

Gene Synonyms/Alias

 TMEM48 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
403	SYPVEPKKLNSPEET	ubiquitination	[1, 2]
430	PSVPPLVKTSLFSSK	ubiquitination	[2, 3, 4, 5]
437	KTSLFSSKLSTPDVV	ubiquitination	[1, 2, 3, 5, 6]
510	TSISAEGKTMRQPSV	ubiquitination	[1]
628	SLVDTSYKTLRFAFR	ubiquitination	[1, 3, 5]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. 

Sequence Annotation

 MOD_RES 406 406 Phosphoserine.
 MOD_RES 414 414 Phosphothreonine.
 MOD_RES 439 439 Phosphoserine.
 MOD_RES 440 440 Phosphothreonine.
 MOD_RES 445 445 Phosphoserine.
 MOD_RES 449 449 Phosphothreonine.
 MOD_RES 471 471 Phosphoserine.
 MOD_RES 474 474 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 674 AA 

Protein Sequence

Gene Ontology

 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IDA:UniProtKB.
 GO:0017056; F:structural constituent of nuclear pore; IMP:UniProtKB.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051292; P:nuclear pore complex assembly; IMP:UniProtKB.
 GO:0031081; P:nuclear pore distribution; IMP:UniProtKB.
 GO:0015031; P:protein transport; NAS:UniProtKB. 

Interpro

 IPR019049; Nucleoporin_prot_Ndc1/Nup. 

Pfam

 PF09531; Ndc1_Nup 

SMART

  

PROSITE

  

PRINTS