UniProt Accession

 TPH2_HUMAN; Q8IWU9; A6NGA4; Q14CB0 

Genbank Protein ID

 AY098914; AC090109; BC114499 

Genbank Nucleotide ID

 AAM28946.1; AAI14500.1 

Protein Name

 Tryptophan 5-hydroxylase 2 

Protein Synonyms/Alias

 Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2 

Gene Name

 TPH2 

Gene Synonyms/Alias

 NTPH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	NEVGGLVKALRLFQE	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 DOMAIN 65 140 ACT.
 METAL 318 318 Iron (By similarity).
 METAL 323 323 Iron (By similarity).
 METAL 363 363 Iron (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Polymorphism; Reference proteome; RNA editing; Serotonin biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0016597; F:amino acid binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004510; F:tryptophan 5-monooxygenase activity; IEA:EC.
 GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
 GO:0071285; P:cellular response to lithium ion; IEA:Compara.
 GO:0007623; P:circadian rhythm; IEA:Compara.
 GO:0046219; P:indolalkylamine biosynthetic process; TAS:Reactome.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara.
 GO:0042427; P:serotonin biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR002912; ACT_dom.
 IPR001273; ArAA_hydroxylase.
 IPR018301; ArAA_hydroxylase_Fe/CU_BS.
 IPR019774; Aromatic-AA_hydroxylase_C.
 IPR005963; Trp_5_mOase.
 IPR019773; Tyrosine_3-monooxygenase-like. 

Pfam

 PF01842; ACT
 PF00351; Biopterin_H 

SMART

  

PROSITE

 PS51671; ACT
 PS00367; BH4_AAA_HYDROXYL_1
 PS51410; BH4_AAA_HYDROXYL_2 

PRINTS

 PR00372; FYWHYDRXLASE.