UniProt Accession

 CDIPT_MOUSE; Q8VDP6 

Genbank Protein ID

 AK076974; AK079226; AK089109; BC021473; BC024413 

Genbank Nucleotide ID

 BAC36542.1; BAC37580.1; BAC40756.1; AAH21473.1; AAH24413.1 

Protein Name

 CDP-diacylglycerol--inositol 3-phosphatidyltransferase 

Protein Synonyms/Alias

 Phosphatidylinositol synthase; PI synthase; PtdIns synthase 

Gene Name

 Cdipt 

Gene Synonyms/Alias

 Pis1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
121	VRGSESHKMIDLSGN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). 

Sequence Annotation

  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Lipid biosynthesis; Lipid metabolism; Manganese; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043178; F:alcohol binding; IEA:Compara.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0003881; F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; IEA:EC.
 GO:0019992; F:diacylglycerol binding; IEA:Compara.
 GO:0030145; F:manganese ion binding; IEA:Compara.
 GO:0046341; P:CDP-diacylglycerol metabolic process; IEA:Compara.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Compara. 

Interpro

 IPR000462; CDP-OH_P_trans.
 IPR014387; CDP_diag_ino_3_P_euk. 

Pfam

 PF01066; CDP-OH_P_transf 

SMART

  

PROSITE

 PS00379; CDP_ALCOHOL_P_TRANSF 

PRINTS