UniProt Accession

 S15A4_HUMAN; Q8N697; A6H8Y9; B3KTK1; Q71M34; Q7Z5F8; Q8TAH0 

Genbank Protein ID

 AY050629; AY038999; AF461893; AK095717; CH471054; BC028394; BC146803 

Genbank Nucleotide ID

 AAK95565.1; AAK72099.1; AAQ04807.1; BAG53113.1; EAW98494.1; AAH28394.2; AAI46804.1 

Protein Name

 Solute carrier family 15 member 4 

Protein Synonyms/Alias

 Peptide transporter 4; Peptide/histidine transporter 1; hPHT1 

Gene Name

 SLC15A4 

Gene Synonyms/Alias

 PHT1; PTR4; FP12591 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
272	TYSCCSQKRSGERQS	ubiquitination	[1, 2, 3]
292	GVFQQSSKQSLFDSC	ubiquitination	[1, 2, 3, 4, 5, 6, 7, 8]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides. 

Sequence Annotation

 MOD_RES 291 291 Phosphoserine (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Membrane; Peptide transport; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 577 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; TAS:Reactome.
 GO:0005290; F:L-histidine transmembrane transporter activity; IEA:Compara.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0006811; P:ion transport; TAS:Reactome.
 GO:0006857; P:oligopeptide transport; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR016196; MFS_dom_general_subst_transpt.
 IPR000109; POT_fam.
 IPR018456; PTR2_symporter_CS. 

Pfam

 PF00854; PTR2 

SMART

  

PROSITE

 PS01023; PTR2_2 

PRINTS