UniProt Accession

 G5EA52_HUMAN; G5EA52 

Genbank Protein ID

 AC018512; CH471082 

Genbank Nucleotide ID

 EAW77235.1 

Protein Name

 Protein disulfide isomerase family A, member 3, isoform CRA_b 

Protein Synonyms/Alias

 Protein disulfide-isomerase A3 

Gene Name

 PDIA3 

Gene Synonyms/Alias

 hCG_38001 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	ANTNTCNKYGVSGYP	ubiquitination	[1, 2]
84	VSGYPTLKIFRDGEE	ubiquitination	[1, 2]
198	LTNKFEDKTVAYTEQ	acetylation	[3]
276	KFLDAGHKLNFAVAS	ubiquitination	[1]
285	NFAVASRKTFSHELS	ubiquitination	[1]
315	IRTAKGEKFVMQEEF	ubiquitination	[1]
342	DYFDGNLKRYLKSEP	ubiquitination	[1]
405	ELGEKLSKDPNIVIA	acetylation	[3]
405	ELGEKLSKDPNIVIA	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Disulfide bond; Isomerase; Redox-active center; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 485 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro. 

Interpro

 IPR005788; Disulphide_isomerase.
 IPR005792; Prot_disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.