CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042252
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Isocitrate dehydrogenase [NADP] 
Protein Synonyms/Alias
  
Gene Name
 Idh1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
58ATHDQVTKDAAEAIKacetylation[1]
81ATITPDEKRVEEFKLacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 
Functional Description
  
Sequence Annotation
 NP_BIND 75 77 NADP (By similarity).
 NP_BIND 310 315 NADP (By similarity).
 REGION 94 100 Substrate binding (By similarity).
 METAL 252 252 Magnesium or manganese (By similarity).
 METAL 275 275 Magnesium or manganese (By similarity).
 BINDING 77 77 Substrate (By similarity).
 BINDING 82 82 NADP (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 132 132 Substrate (By similarity).
 BINDING 260 260 NADP (By similarity).
 BINDING 328 328 NADP; via amide nitrogen and carbonyl  
Keyword
 Complete proteome; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 414 AA 
Protein Sequence
MSRKIHGGSV VEMQGDEMTR VIWELIKEKL IFPYVELDLH SYDLGIENRD ATHDQVTKDA 60
AEAIKKYNVG IKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL 120
VSGWLKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GSQKVTYLVH NFEEGGGVAM 180
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE 240
AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG 300
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK ELDFFAKALE 360
EVCIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKTKLA QAKL 414 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS