UniProt Accession

 PHLA1_HUMAN; Q8WV24; A1A4G9; Q15184; Q2TAN2; Q9NZ17 

Genbank Protein ID

 AF239986; Z50194; BC018929; BC110820; BC126425; AF220656 

Genbank Nucleotide ID

 AAF64165.1; CAA90576.1; AAH18929.3; AAI10821.1; AAI26426.2; AAF36387.1 

Protein Name

 Pleckstrin homology-like domain family A member 1 

Protein Synonyms/Alias

 Apoptosis-associated nuclear protein; Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; Proline- and histidine-rich protein; T-cell death-associated gene 51 protein 

Gene Name

 PHLDA1 

Gene Synonyms/Alias

 PHRIP; TDAG51 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	SSGCKALKEGVLEKR	ubiquitination	[1, 2]
168	DGLLQLWKKKCCILT	ubiquitination	[1, 2]
230	LEPPVKLKELHFSNM	ubiquitination	[1, 2]
238	ELHFSNMKTVDCVER	acetylation	[3]
293	RQAILAVKSTRQKQQ	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. 

Sequence Annotation

 DOMAIN 151 283 PH.
 REGION 311 346 15 X 2 AA repeats of P-Q.
 REGION 352 389 14 X 2 AA repeats of P-H.  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Membrane; Nucleus; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 401 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0045210; P:FasL biosynthetic process; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara. 

Interpro

 IPR001849; Pleckstrin_homology. 

Pfam

  

SMART

 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN 

PRINTS