UniProt Accession

 AL7A1_MOUSE; Q9DBF1; Q3TFC7; Q3TVH7; Q3UKT6 

Genbank Protein ID

 AK004991; AK145873; AK160117; AK169195; BC012407 

Genbank Nucleotide ID

 BAB23726.1; BAE26715.1; BAE35641.1; BAE40971.1; AAH12407.1 

Protein Name

 Alpha-aminoadipic semialdehyde dehydrogenase 

Protein Synonyms/Alias

 Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase 

Gene Name

 Aldh7a1 

Gene Synonyms/Alias

 Ald7a1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
86	RVRQASLKDYEETIG	ubiquitination	[1]
94	DYEETIGKAKKAWNI	ubiquitination	[1]
97	ETIGKAKKAWNIWAD	ubiquitination	[1]
109	WADIPAPKRGEIVRK	ubiquitination	[1]
116	KRGEIVRKIGDAFRE	ubiquitination	[1]
124	IGDAFREKIQLLGRL	ubiquitination	[1]
375	LYGPLHTKQAVSMFV	acetylation	[2, 3, 4]
375	LYGPLHTKQAVSMFV	succinylation	[3]
389	VRAVEEAKKQGGTVV	acetylation	[4]
390	RAVEEAKKQGGTVVY	acetylation	[3]
390	RAVEEAKKQGGTVVY	succinylation	[3]
452	FEWNNEVKQGLSSSI	ubiquitination	[1]
462	LSSSIFTKDLGRIFR	ubiquitination	[1]
500	GGAFGGEKHTGGGRE	ubiquitination	[1]
514	ESGSDAWKQYMRRST	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). 

Sequence Annotation

 NP_BIND 274 279 NAD (By similarity).
 ACT_SITE 296 296 Proton acceptor (By similarity).
 ACT_SITE 330 330 Nucleophile (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Mitochondrion; NAD; Nucleus; Oxidoreductase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 539 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:EC.
 GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase activity; IEA:EC.
 GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS