| Tag | Content |
|---|
| CPLM ID | CPLM-018526 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SH3 domain-containing protein 19 |
Protein Synonyms/Alias | Kryn |
Gene Name | Sh3d19 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 18 | NTIVSRIKAFEGQTN | ubiquitination | [1] | | 34 | EIPGLPKKPEIIPRT | ubiquitination | [1] | | 52 | KPAVSSGKPLVAPKP | ubiquitination | [1] | | 100 | AGITPVTKPELPKKP | ubiquitination | [1] | | 106 | TKPELPKKPTPGLTR | ubiquitination | [1] | | 177 | LSVASQAKAFRSLGE | ubiquitination | [1] | | 359 | PASKSSNKNLPFNRS | ubiquitination | [1] | | 375 | SDMDLQKKQSHFVSG | ubiquitination | [1] | | 411 | PGHPLYRKYMLSVPH | ubiquitination | [1] | | 436 | NPTELSCKRGDVLVI | ubiquitination | [1] | | 469 | RVHPSQMKIVTPLDE | ubiquitination | [1] | | 571 | SFSSHCAKGPRCVAR | ubiquitination | [1] | | 641 | GANILSTKVPPKTKN | ubiquitination | [1] | | 722 | QPCPAEAKGVASAIP | ubiquitination | [1] | | 730 | GVASAIPKGRKVKAL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). |
Sequence Annotation | DOMAIN 417 472 SH3 1.
DOMAIN 494 553 SH3 2.
DOMAIN 570 629 SH3 3.
DOMAIN 660 719 SH3 4.
DOMAIN 729 788 SH3 5.
MOD_RES 676 676 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 789 AA |
Protein Sequence | MNIMNTEQSQ NTIVSRIKAF EGQTNTEIPG LPKKPEIIPR TIPPKPAVSS GKPLVAPKPA 60
ANRASGEWDT WAENRLKVTS REGLTPYSSP QEAGITPVTK PELPKKPTPG LTRSVNHETS 120
GGRPMAESPD TGKKIPTPAP RPLLPKKSAS TDAPPYPSIP PKLVSAPPRL SVASQAKAFR 180
SLGEGLPSNP PVPAPQSKAL GDIDLISFDD DVLPTSGSPA EEPTGSETVL DPFQLPTKTE 240
ATKERAVQPA PTRKPTVIRI PAKPGKCLHE EPQSPPPLPA EKPVGNTHSA VSGRPSHSDR 300
TRNPELEQAS ESGGLVQGPP RLPPRPVHGK VIPVWRPPPK GAPERPPPPK LPASKSSNKN 360
LPFNRSSSDM DLQKKQSHFV SGLSKAKSQI FKNQDPVLPP RPKPGHPLYR KYMLSVPHGI 420
ANEDIVSRNP TELSCKRGDV LVILKQAENN YLECQRGEGT GRVHPSQMKI VTPLDERPRG 480
RPNDSGHSQK PVDSGAPHAV ALHDFPAEQA DDLSLTSGEI VYLLEKIDAE WYRGKCRNQT 540
GVFPANYVKV IVDIPEGRSG KRESFSSHCA KGPRCVARFE YIGDQKDELS FSEGEVIILT 600
EYVNEEWGRG EIRDRSGIFP LNFVELVGDH PTSGANILST KVPPKTKNED PGSNSQDSSP 660
PGEWCKALHS FTAETSEDLP FKRGDRILIL ERLDSDWYRG RLHDREGIFP AVFVQPCPAE 720
AKGVASAIPK GRKVKALYDF LGENEDELSF KAGDVITELE PIDDAWMRGE LMGRAGMFPK 780
NYVQFLQVS 789 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:Compara. GO:0005634; C:nucleus; IEA:Compara. GO:0005886; C:plasma membrane; IEA:Compara. GO:0007010; P:cytoskeleton organization; ISS:UniProtKB. GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Compara. GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |