UniProt Accession

 RL1_THET8; Q5SLP7 

Genbank Protein ID

 AP008226 

Genbank Nucleotide ID

 BAD70069.1 

Protein Name

 50S ribosomal protein L1 

Protein Synonyms/Alias

  

Gene Name

 rplA 

Gene Synonyms/Alias

 TTHA0246 

Created Date

 July 27, 2013 

Organism

 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 

NCBI Taxa ID

 300852 

Lysine Modification

Position	Peptide	Type	References
14	RYRALLEKVDPNKVY	acetylation	[1]

Reference

 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 

Functional Description

 Directly binds to 23S rRNA. Forms what is known as the L1 stalk, which protrudes beyond the 70S ribosome surface. The stalk is preferentially stabilized in 70S versus 50S crystals. Interacts with the E site tRNA, blocking the exit path. This blockage implies that this section of the ribosome must be able to move to release the deacetylated tRNA. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Reference proteome; Repressor; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding; Translation regulation; tRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0019843; F:rRNA binding; IEA:HAMAP.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR005878; Ribosom_L1_bac-type.
 IPR002143; Ribosomal_L1.
 IPR016094; Ribosomal_L1_2-a/b-sand.
 IPR016095; Ribosomal_L1_3-a/b-sand.
 IPR023673; Ribosomal_L1_CS.
 IPR023674; Ribosomal_L1_SF. 

Pfam

 PF00687; Ribosomal_L1 

SMART

  

PROSITE

 PS01199; RIBOSOMAL_L1 

PRINTS