CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002899
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 3-phosphoshikimate 1-carboxyvinyltransferase 
Protein Synonyms/Alias
 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS 
Gene Name
 aroA 
Gene Synonyms/Alias
 b0908; JW0891 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
22TINLPGSKSVSNRALacetylation[1]
139ALRLGGAKITYLEQEacetylation[1]
198IKGDLVSKPYIDITLacetylation[1]
340NIYNWRVKETDRLFAacetylation[1]
373IRITPPEKLNFAEIAacetylation[1]
411LDPKCTAKTFPDYFEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Cytoplasm; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 427 AA 
Protein Sequence
MESLTLQPIA RVDGTINLPG SKSVSNRALL LAALAHGKTV LTNLLDSDDV RHMLNALTAL 60
GVSYTLSADR TRCEIIGNGG PLHAEGALEL FLGNAGTAMR PLAAALCLGS NDIVLTGEPR 120
MKERPIGHLV DALRLGGAKI TYLEQENYPP LRLQGGFTGG NVDVDGSVSS QFLTALLMTA 180
PLAPEDTVIR IKGDLVSKPY IDITLNLMKT FGVEIENQHY QQFVVKGGQS YQSPGTYLVE 240
GDASSASYFL AAAAIKGGTV KVTGIGRNSM QGDIRFADVL EKMGATICWG DDYISCTRGE 300
LNAIDMDMNH IPDAAMTIAT AALFAKGTTT LRNIYNWRVK ETDRLFAMAT ELRKVGAEVE 360
EGHDYIRITP PEKLNFAEIA TYNDHRMAMC FSLVALSDTP VTILDPKCTA KTFPDYFEQL 420
ARISQAA 427 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferase activity; IEA:EC.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
 GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001986; Enolpyruvate_Tfrase_dom.
 IPR006264; EPSP_synthase.
 IPR023193; EPSP_synthase_CS.
 IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b. 
Pfam
 PF00275; EPSP_synthase 
SMART
  
PROSITE
 PS00104; EPSP_SYNTHASE_1
 PS00885; EPSP_SYNTHASE_2 
PRINTS