CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020248
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin p58/p45 
Protein Synonyms/Alias
 Nucleoporin-like protein 1 
Gene Name
 NUPL1 
Gene Synonyms/Alias
 KIAA0410 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
260QDVENLQKFVKEQKQubiquitination[1]
266QKFVKEQKQVQEEISubiquitination[1]
278EISRMSSKAMLKVQEubiquitination[1, 2]
291QEDIKALKQLLSLAAubiquitination[1, 3, 4]
312TLNIDKLKIETAQELubiquitination[1]
320IETAQELKNAEIALRubiquitination[1]
330EIALRTQKTPPGLQHubiquitination[3, 4]
422EQYLGYRKMFLGDAVubiquitination[1, 2, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity). 
Sequence Annotation
 REPEAT 7 8 1.
 REPEAT 30 31 2.
 REPEAT 44 45 3.
 REPEAT 63 64 4.
 REPEAT 68 69 5.
 REPEAT 488 489 6.
 REPEAT 492 493 7.
 REPEAT 513 514 8.
 REPEAT 519 520 9.
 REPEAT 529 530 10.
 REPEAT 531 532 11.
 REPEAT 545 546 12.
 REPEAT 568 569 13.
 REPEAT 578 579 14.
 REGION 7 579 14 X 2 AA repeats of F-G.
 MOD_RES 331 331 Phosphothreonine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Glycoprotein; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 599 AA 
Protein Sequence
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS 60
SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT 120
PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG 180
SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK 240
ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG 300
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY 360
RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY 420
RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGP 480
QPSLGVSFGT PFGSGIGTGL QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS 540
LSAGFGSSST SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR 599 
Gene Ontology
 GO:0005635; C:nuclear envelope; TAS:Reactome.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005487; F:nucleocytoplasmic transporter activity; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0015758; P:glucose transport; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010827; P:regulation of glucose transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 
Interpro
 IPR024882; Nucleoporin_p58/p45. 
Pfam
  
SMART
  
PROSITE
  
PRINTS