CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041278
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gasdermin domain containing 1, isoform CRA_d 
Protein Synonyms/Alias
 Gasdermin-D 
Gene Name
 GSDMD 
Gene Synonyms/Alias
 GSDMDC1; hCG_32063 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91PYCLVVRKPSSSWFWubiquitination[1]
99PSSSWFWKPRYKCVNubiquitination[1, 2]
103WFWKPRYKCVNLSIKubiquitination[1]
110KCVNLSIKDILEPDAubiquitination[1]
193HLRQPEHKVLQQLRSubiquitination[1, 3]
252QGHLSQKKTVTIPSGubiquitination[1, 3]
296QPPATGHKRSTSEGAubiquitination[1]
347AEVETISKELELLDRubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MISAHCNLHL PGSSDSLASA SQLLLAGRLP GRADAPDAPP SGRRRSRSMG SAFERVVRRV 60
VQELDHGGEF IPVTSLQSST GFQPYCLVVR KPSSSWFWKP RYKCVNLSIK DILEPDAAEP 120
DVQRGRSFHF YDAMDGQIQG SVELAAPGQA KIAGGAAVSD SSSTSMNVYS LSVDPNTWQT 180
LLHERHLRQP EHKVLQQLRS RGDNVYVVTE VLQTQKEVEV TRTHKREGSG RFSLPGATCL 240
QGEGQGHLSQ KKTVTIPSGS TLAFRVAQLV IDSDLDVLLF PDKKQRTFQP PATGHKRSTS 300
EGAWPQLPSG LSMMRCLHNF LTDGVPAEGA FTEDFQGLRA EVETISKELE LLDRELCQLL 360
LEGLEGVLRD QLALRALEEA LEQGQSLGPV EPLDGPAGAV LECLVLSSGM LVPELAIPVV 420
YLLGALTMLS ETQHKLLAEA LESQTLLGPL ELVGSLLEQS APWQERSTMS LPPGLLGNSW 480
GEGAPAWVLL DECGLELGED TPHVCWEPQA QGRMCALYAS LALLSGLSQE PH 532 
Gene Ontology
  
Interpro
 IPR007677; Gasdermin. 
Pfam
 PF04598; Gasdermin 
SMART
  
PROSITE
  
PRINTS