CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037214
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein timeless homolog 
Protein Synonyms/Alias
  
Gene Name
 TIMELESS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
288SYIVQGLKSIGERDLubiquitination[1, 2]
299ERDLIFHKGLHNLRNubiquitination[1, 2]
313NYSSDLGKQPKKVPKubiquitination[2]
582TFWRIPAKLSPTQLRacetylation[3]
582TFWRIPAKLSPTQLRubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 705 AA 
Protein Sequence
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD VRQQLGAAQI 60
LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL PKEPSFRHHF LQVLTYLQAY 120
KEAFASEKAF GVLSETLYEL LQLGWEERQE EDNLLIERIL LLVRNILHVP ADLDQEKKID 180
DDASAHDQLL WAIHLSGLDD LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG 240
RLAQERSADF AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG 300
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL NTVPRTRKQI 360
IHHLVQMGLA DSVKDFQRKG THIVLWTGDQ ELELQRLFEE FRDSDDVLGH IMKNITAKRS 420
RARIVDKLLA LGLVAERREL YKKRQKKLAS SILPNGAESL KDFCQEDLEE EENLPEEDSE 480
EEEEGGSEAE QVQGSLVLSN ENLGQSLHQE GFSIPLLWLQ NCLIRAADDR EEDGCSQAVP 540
LVPLTEENEE AMENEQFQQL LRKLGVRPPA SGQETFWRIP AKLSPTQLRR AAASLSQPEE 600
EQKLQPELQP KVPGEQGSDE EHCKEHRAQA LRALLLAHKK KAGLASPEEE DAVGKEPLKA 660
APKKRQLLDS DEEQEEDEGR NRAPELGAPG IQKKKRYQIE DDEDD 705 
Gene Ontology
  
Interpro
 IPR006906; Timeless.
 IPR007725; TIMELESS_C. 
Pfam
 PF04821; TIMELESS
 PF05029; TIMELESS_C 
SMART
  
PROSITE
  
PRINTS