| Tag | Content |
|---|
| CPLM ID | CPLM-002321 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Uroporphyrinogen-III synthase |
Protein Synonyms/Alias | UROIIIS; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase |
Gene Name | HEM4 |
Gene Synonyms/Alias | ORF1; YOR278W; O5463 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 258 | TSDVVSPKPDPKSLL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Heme biosynthesis; Lyase; Porphyrin biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 275 AA |
Protein Sequence | MSSRKKVRVL LLKNKTVPID KYELECRSKA FEPIFVPLIK HTHVIQDFRN VLNTIPNYLN 60
TINYIIITSQ RTVESLNEAI IPTLTSEQKA ALLSKTVYTV GPATANFIRR SGFINVKGGE 120
DAGNGSILAD IIIDDLSTDI KACPPSELLF LVGEIRRDII PKKLHSKGIK VREVVTYKTE 180
ELSDGFKRFI HAMKECDEDE VFSDWVVVFS PQGTKEITQY LGDSNRLPGS HLRVASIGPT 240
TKKYLDDNDV TSDVVSPKPD PKSLLDAIEL YQRHK 275 |
Gene Ontology | GO:0004852; F:uroporphyrinogen-III synthase activity; IMP:SGD. GO:0006783; P:heme biosynthetic process; IMP:SGD. GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |