| Tag | Content |
|---|
| CPLM ID | CPLM-019239 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | AMSH-like protease |
Protein Synonyms/Alias | AMSH-LP; STAM-binding protein-like 1 |
Gene Name | STAMBPL1 |
Gene Synonyms/Alias | AMSHLP; KIAA1373 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 12 | FTVNSLKKLAAMPDH | ubiquitination | [1] | | 111 | QDIMKKLKEIAFPRT | ubiquitination | [1] | | 128 | LKNDLLKKYNVEYQE | ubiquitination | [1] | | 142 | EYLQSKNKYKAEILK | ubiquitination | [1] | | 144 | LQSKNKYKAEILKKL | ubiquitination | [1] | | 278 | LPEDLCHKFLQLAES | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. |
Sequence Annotation | DOMAIN 264 373 MPN.
MOTIF 347 360 JAMM motif.
METAL 347 347 Zinc 1; catalytic.
METAL 349 349 Zinc 1; catalytic.
METAL 360 360 Zinc 1; catalytic.
METAL 362 362 Zinc 2.
METAL 402 402 Zinc 2.
METAL 408 408 Zinc 2.
METAL 410 410 Zinc 2.
MOD_RES 25 25 Phosphoserine.
MOD_RES 242 242 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; Ubl conjugation pathway; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 436 AA |
Protein Sequence | MDQPFTVNSL KKLAAMPDHT DVSLSPEERV RALSKLGCNI TISEDITPRR YFRSGVEMER 60
MASVYLEEGN LENAFVLYNK FITLFVEKLP NHRDYQQCAV PEKQDIMKKL KEIAFPRTDE 120
LKNDLLKKYN VEYQEYLQSK NKYKAEILKK LEHQRLIEAE RKRIAQMRQQ QLESEQFLFF 180
EDQLKKQELA RGQMRSQQTS GLSEQIDGSA LSCFSTHQNN SLLNVFADQP NKSDATNYAS 240
HSPPVNRALT PAATLSAVQN LVVEGLRCVV LPEDLCHKFL QLAESNTVRG IETCGILCGK 300
LTHNEFTITH VIVPKQSAGP DYCDMENVEE LFNVQDQHDL LTLGWIHTHP TQTAFLSSVD 360
LHTHCSYQLM LPEAIAIVCS PKHKDTGIFR LTNAGMLEVS ACKKKGFHPH TKEPRLFSIC 420
KHVLVKDIKI IVLDLR 436 |
Gene Ontology | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |