CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transducin-like enhancer protein 3 
Protein Synonyms/Alias
  
Gene Name
 TLE3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
348GLRSMPGKPPGMDPIubiquitination[1, 2]
522DISQPGSKSPISQLDubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 774 AA 
Protein Sequence
MPPPPPLSCL RGLQAPHQPG QPGFKFTVAE SCDRIKDEFQ FLQAQYHSLK VEYDKLANEK 60
TEMQRHYVMY YEMSYGLNIE MHKQTEIAKR LNTILAQIMP FLSQEHQQQV AQAVERAKQV 120
TMTELNAIIG QQLQAQHLSH ATHGPPVQLP PHPSGLQPPG IPPVTGSSSG LLALGALGSQ 180
AHLTVKDEKN HHELDHRERE SSANNSVSPS ESLRASEKHR GSADYSMEAK KRKAEEKDSL 240
SRYDSDGDKS DDLVVDVSNE DPATPRVSPA HSPPENGLDK ARSLKKDAPT SPASVASSSS 300
TPSSKTKDLG HNDKSSTPGL KSNTPTPRND APTPGTSTTP GLRSMPGKPP GMDPIASALR 360
TPISITSSYA APFAMMSHHE MNGSLTSPGA YAGLHNIPPQ MSAAAAAAAA AYGRSPMVSF 420
GAVGFDPHPP MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR 480
QINTLSHGEV VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC 540
KLLPDGRTLI VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCCSDG 600
NIAVWDLHNQ TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF 660
TSQIFSLGYC PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST 720
GKDNLLNAWR TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY 774 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR005617; Groucho/TLE_N.
 IPR009146; Groucho_enhance.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03920; TLE_N
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR01850; GROUCHOFAMLY.