CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037150
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Lysine-specific demethylase 5A 
Protein Synonyms/Alias
  
Gene Name
 KDM5A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45RIRPLAEKTGICKIRubiquitination[1, 2]
332LCPCPMQKKCLRYRYubiquitination[1, 3]
333CPCPMQKKCLRYRYPubiquitination[1]
352PSLLYGVKVRAQSYDubiquitination[1, 3]
377SANFNHKKDLIELRVubiquitination[1]
393LEDAEDRKYPENDLFubiquitination[1]
408RKLRDAVKEAETCASubiquitination[1]
424AQLLLSKKQKHRQSPubiquitination[1]
439DSGRTRTKLTVEELKubiquitination[1]
466ISQARQVKNLLDDVEubiquitination[1]
514LPELPRLKQELQQARubiquitination[1]
543VTLDVMKKLIDSGVGacetylation[2]
543VTLDVMKKLIDSGVGubiquitination[1]
601ESIVNEAKNIPAFLPubiquitination[1]
648QLESLSAKGRPIPVRubiquitination[1]
706IGVYGSGKNRRKKVKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 715 AA 
Protein Sequence
MAGVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PLAEKTGICK IRPPKEYALS 60
GWNLNNMPVL EQSVLAHINV DISGMKVPWL YVGMCFSSFC WHIEDHWSYS INYLHWGEPK 120
TWYGVPSHAA EQLEEVMREL APELFESQPD LLHQLVTIMN PNVLMEHGVP VYRTNQCAGE 180
FVVTFPRAYH SGFNQGYNFA EAVNFCTADW LPIGRQCVNH YRRLRRHCVF SHEELIFKMA 240
ADPECLDVGL AAMVCKELTL MTEEETRLRE SVVQMGVLMS EEEVFELVPD DERQCSACRT 300
TCFLSALTCS CNPERLVCLY HPTDLCPCPM QKKCLRYRYP LEDLPSLLYG VKVRAQSYDT 360
WVSRVTEALS ANFNHKKDLI ELRVMLEDAE DRKYPENDLF RKLRDAVKEA ETCASVAQLL 420
LSKKQKHRQS PDSGRTRTKL TVEELKAFVQ QLFSLPCVIS QARQVKNLLD DVEEFHERAQ 480
EAMMDETPDS SKLQMLIDMG SSLYVELPEL PRLKQELQQA RWLDEVRLTL SDPQQVTLDV 540
MKKLIDSGVG LAPHHAVEKA MAELQELLTV SERWEEKAKV CLQARPRHSV ASLESIVNEA 600
KNIPAFLPNV LSLKEALQKA REWTAKVEAI QSGSNYAYLE QLESLSAKGR PIPVRLEALP 660
QVESQVAAAR AWRERTGRTF LKKNSSHTLL QVLSPRTDIG VYGSGKNRRK KVKEL 715 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016706; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IEA:InterPro. 
Interpro
 IPR003347; JmjC_dom.
 IPR013637; Lys_sp_deMease_like_dom.
 IPR003349; TF_JmjN.
 IPR004198; Znf_C5HC2. 
Pfam
 PF02373; JmjC
 PF02375; JmjN
 PF08429; PLU-1
 PF02928; zf-C5HC2 
SMART
 SM00558; JmjC
 SM00545; JmjN 
PROSITE
 PS51184; JMJC
 PS51183; JMJN 
PRINTS