UniProt Accession

 STYL1_HUMAN; Q9Y6J8; Q9UBP1; Q9UK06; Q9UK07; Q9UKG2; Q9UKG3 

Genbank Protein ID

 AF069762; AC006330; BC024035; AF188201; AF188202; AF188203; AF188204; AF169647; AF169648 

Genbank Nucleotide ID

 AAD36983.1; AAS07535.1; AAH24035.1; AAF04111.1; AAF04112.1; AAF04113.1; AAF04114.1; AAD53723.1; AAD53724.1 

Protein Name

 Serine/threonine/tyrosine-interacting-like protein 1 

Protein Synonyms/Alias

 Dual specificity phosphatase inhibitor MK-STYX; Dual specificity protein phosphatase 24; Map kinase phosphatase-like protein MK-STYX 

Gene Name

 STYXL1 

Gene Synonyms/Alias

 DUSP24; MKSTYX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	NILNQATKLSRLTDP	ubiquitination	[1]
39	CLLDVRSKWEYDESH	ubiquitination	[1, 2]
128	HHPVYILKGGYERFS	ubiquitination	[2]
145	YHFLRTQKIIWMPQE	ubiquitination	[2]
278	RSWAYVKKCKNNMCP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. 

Sequence Annotation

 DOMAIN 17 140 Rhodanese.
 DOMAIN 160 301 Tyrosine-protein phosphatase.  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc. 

Interpro

 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR001763; Rhodanese-like_dom. 

Pfam

 PF00782; DSPc
 PF00581; Rhodanese 

SMART

 SM00195; DSPc
 SM00450; RHOD 

PROSITE

 PS50206; RHODANESE_3
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 

PRINTS