CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022683
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Toll-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 Tollip 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
63SITVVQAKLAKNYGMubiquitination[1]
66VVQAKLAKNYGMTRMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. 
Sequence Annotation
 DOMAIN 40 135 C2.
 DOMAIN 229 272 CUE.  
Keyword
 Complete proteome; Cytoplasm; Immunity; Inflammatory response; Innate immunity; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 274 AA 
Protein Sequence
MATTVSTQRG PVYIGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGTVG TVGRLSITVV 60
QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF 120
DERAFSMDDR IAWTHITIPE SLKQGQVEDE WYSLSGRQGD DKEGMINLVM SYTSLPAAMM 180
MPPQPVVLMP TVYQQGVGYV PIAGMPAVCS PGMVPMAMPP PAVAPQPRCN EEDLKAIQDM 240
FPNMDREVIR SVLEAQRGNK DAAINSLLQM GEES 274 
Gene Ontology
 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0016310; P:phosphorylation; ISS:UniProtKB.
 GO:0033235; P:positive regulation of protein sumoylation; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR003892; CUE.
 IPR009060; UBA-like. 
Pfam
 PF00168; C2
 PF02845; CUE 
SMART
 SM00239; C2
 SM00546; CUE 
PROSITE
 PS50004; C2
 PS51140; CUE 
PRINTS