CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021074
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C-terminal-binding protein 2 
Protein Synonyms/Alias
 CtBP2 
Gene Name
 Ctbp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
279RGGLVDEKALAQALKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity). 
Sequence Annotation
 NP_BIND 186 191 NAD (By similarity).
 NP_BIND 243 249 NAD (By similarity).
 NP_BIND 270 272 NAD (By similarity).
 NP_BIND 321 324 NAD (By similarity).
 ACT_SITE 272 272 By similarity.
 ACT_SITE 301 301 By similarity.
 ACT_SITE 321 321 Proton donor (By similarity).
 BINDING 106 106 NAD (By similarity).
 BINDING 210 210 NAD (By similarity).
 BINDING 296 296 NAD (By similarity).
 MOD_RES 428 428 Phosphoserine; by HIPK2 (By similarity).  
Keyword
 Alternative splicing; Cell junction; Complete proteome; Differentiation; NAD; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome; Repressor; Synapse; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC 60
DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG 120
IAVCNIPSAA VEETADSTVC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG 180
ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS 240
LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 300
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE 360
FFVTSTPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP PAMEGIIPGG IPVTHNLPTV 420
AHPSQAPSPN QPTKHGDNRE HPNEQ 445 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0017053; C:transcriptional repressor complex; ISS:UniProtKB.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0050872; P:white fat cell differentiation; ISS:UniProtKB. 
Interpro
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 
SMART
  
PROSITE
 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 
PRINTS