CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017252
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Type II inositol 1,4,5-trisphosphate 5-phosphatase 
Protein Synonyms/Alias
 Inositol polyphosphate-5-phosphatase B; Phosphoinositide 5-phosphatase; 5PTase 
Gene Name
 Inpp5b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
539IEELDVGKVKKLVEEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. 
Sequence Annotation
 DOMAIN 22 148 PH.
 DOMAIN 821 993 Rho-GAP.
 REGION 342 668 5-phosphatase (By similarity).
 REGION 459 460 Substrate binding (By similarity).
 REGION 582 583 Substrate binding (By similarity).
 REGION 596 598 Substrate binding (By similarity).
 REGION 669 782 ASH (By similarity).
 METAL 355 355 Magnesium (By similarity).
 METAL 383 383 Magnesium (By similarity).
 BINDING 383 383 Substrate (By similarity).
 MOD_RES 990 990 Cysteine methyl ester (Potential).
 LIPID 990 990 S-farnesyl cysteine (Potential).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endosome; Golgi apparatus; Hydrolase; Lipoprotein; Magnesium; Membrane; Metal-binding; Methylation; Prenylation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 993 AA 
Protein Sequence
MDQSVAIQET LVEGEYCVIA VQGVLCKGDS RQSRLLGLVR YRLENDAQEH ALFLYTHRRM 60
AITGDDVSLD QIVPLSKDFM LEEVSPDGEL YILGSDVTVQ LNTAELKLVF QLPFGSHTRT 120
FLQEVARACP GFDPETRDPE FEWLSRHTCA EPDAESPKPR EWNSDPGTRS GFAPIGGSRH 180
QSRNARRGLE DVLPRGPGYI LLWGGAAEEP EFLLAEEMHE GGPVRGRRPL AGRRDEALEE 240
ADWEMSAGGG SRERDCAGVS NVDSSRPNGR GPDQPSGARC PEKPENSLTR QNKSKSDMSE 300
KVRSATVTVS DKAHILSVQK FGLRDTIVRS HLVQKEENYT YIQNFRFFVG TYNVNGQSPK 360
ECLRPWLSHS ALAPDVYCVG FQELDLSKEA FFFHDTPKEE EWFKAVSESL HPDAKYAKVK 420
FVRLVGIMLL LYVKQEHAAY ISEVEAETVG TGIMGRMGNK GGVAIRFQLH NTSICVVNSH 480
LAAHTEEYER RNQDYRDICS RMQFPQVDPS QPPLTINKHD VILWLGDLNY RIEELDVGKV 540
KKLVEEKAFQ TLYAHDQLKI QVAARTIFDG FTEGEITFQP TYKYDTGSDD WDTSEKCRAP 600
AWCDRILWKG KNITQLSYQS HMALKTSDHK PVSSVFDIGV RVVNEELYRK TLEEIVRSLD 660
KMENANIPSV TLSKREFCFE NVKYMQLQTE SFTIHNSQVP CQFEFINKPD EESYCKQWLT 720
ARPSKGFLLP DSHVEIELEL FVNKSTATKL NSGKDTIEDI LVLHLERGKD YFLSVSGNYL 780
PSCFGSPIHT LCYMREPILD LPLKTVSDLT LMSVQTADDR SQLENPMEIP KELWMMVDYL 840
YRNAVQQEDL FQQPGLRPEF DHIRDCLDTG MIDQLCANNH SVAEALLLFL ESLPEPVICY 900
SAYHSCLECS GNYAASKQII LTLPSFHKNV FNYLMAFLQE LLKNSANNHL DENILASIFG 960
SLLLRNPARH QKLDMAEKKK AQEFIHQFLC GPL 993 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IDA:MGI.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.
 GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; ISA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:UniProtKB.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.
 GO:0070613; P:regulation of protein processing; IMP:MGI.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0030317; P:sperm motility; IMP:MGI.
 GO:0007283; P:spermatogenesis; IMP:MGI. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF03372; Exo_endo_phos
 PF00620; RhoGAP 
SMART
 SM00128; IPPc
 SM00324; RhoGAP 
PROSITE
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS