CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005964
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Recombining binding protein suppressor of hairless 
Protein Synonyms/Alias
 J kappa-recombination signal-binding protein; RBP-J kappa 
Gene Name
 Rbpj 
Gene Synonyms/Alias
 Igkjrb1; Igkrsbp; Rbpsuh 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
341FQATPCPKEQNKEMIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. 
Sequence Annotation
 DOMAIN 381 471 IPT/TIG.
 DNA_BIND 84 91 By similarity.
 DNA_BIND 218 227
 DNA_BIND 291 323  
Keyword
 3D-structure; Activator; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Notch signaling pathway; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MPSGFPQSPR TSPRARPKTR ITGALPMDYS EGLSAEERPA HAPSAGKFGE RPPPKRLTRE 60
AMRNYLKERG DQTVLILHAK VAQKSYGNEK RFFCPPPCVY LMGSGWKKKK EQMERDGCSE 120
QESQPCAFIG IGNSDQEMQQ LNLEGKNYCT AKTLYISDSD KRKHFMLSVK MFYGNSDDIG 180
VFLSKRIKVI SKPSKKKQSL KNADLCIASG TKVALFNRLR SQTVSTRYLH VEGGNFHASS 240
QQWGAFYIHL LDDDESEGEE FTVRDGYIHY GQTVKLVCSV TGMALPRLII RKVDKQTALL 300
DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP KEQNKEMIND GASWTIISTD 360
KAEYTFYEGM GPVLAPVTPV PVVESLQLNG GGDVAMLELT GQNFTPNLRV WFGDVEAETM 420
YRCGESMLCV VPDISAFREG WRWVRQPVQV PVTLVRNDGV IYSTSLTFTY TPEPGPRPHC 480
SAAGAILRAN SSQVPSNESN TNSEGNYTNA STNSTSVTSS TATVVS 526 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:InterPro.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISO:MGI.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:MGI.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0036302; P:atrioventricular canal development; IMP:BHF-UCL.
 GO:0009912; P:auditory receptor cell fate commitment; IMP:MGI.
 GO:0030183; P:B cell differentiation; IMP:MGI.
 GO:0097101; P:blood vessel endothelial cell fate specification; IGI:BHF-UCL.
 GO:0072554; P:blood vessel lumenization; IMP:BHF-UCL.
 GO:0001974; P:blood vessel remodeling; IMP:BHF-UCL.
 GO:0003214; P:cardiac left ventricle morphogenesis; IMP:BHF-UCL.
 GO:0042742; P:defense response to bacterium; IMP:MGI.
 GO:0035912; P:dorsal aorta morphogenesis; IMP:BHF-UCL.
 GO:0003160; P:endocardium morphogenesis; IMP:BHF-UCL.
 GO:0009957; P:epidermal cell fate specification; IMP:MGI.
 GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
 GO:0048820; P:hair follicle maturation; IMP:MGI.
 GO:0001947; P:heart looping; TAS:BHF-UCL.
 GO:0006959; P:humoral immune response; IMP:MGI.
 GO:0002437; P:inflammatory response to antigenic stimulus; IMP:MGI.
 GO:0072602; P:interleukin-4 secretion; IMP:MGI.
 GO:0030216; P:keratinocyte differentiation; IMP:MGI.
 GO:0060716; P:labyrinthine layer blood vessel development; IMP:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0030279; P:negative regulation of ossification; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0060853; P:Notch signaling pathway involved in arterial endothelial cell fate commitment; IC:BHF-UCL.
 GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
 GO:0021983; P:pituitary gland development; IMP:MGI.
 GO:0030513; P:positive regulation of BMP signaling pathway; IMP:BHF-UCL.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IMP:BHF-UCL.
 GO:2000138; P:positive regulation of cell proliferation involved in heart morphogenesis; IMP:BHF-UCL.
 GO:1901189; P:positive regulation of ephrin receptor signaling pathway; IMP:BHF-UCL.
 GO:1901186; P:positive regulation of ERBB signaling pathway; IMP:BHF-UCL.
 GO:0035481; P:positive regulation of Notch signaling pathway involved in heart induction; TAS:BHF-UCL.
 GO:0007221; P:positive regulation of transcription of Notch receptor target; ISS:UniProtKB.
 GO:0061344; P:regulation of cell adhesion involved in heart morphogenesis; IC:BHF-UCL.
 GO:0048505; P:regulation of timing of cell differentiation; IMP:MGI.
 GO:0003256; P:regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; IMP:BHF-UCL.
 GO:0048733; P:sebaceous gland development; IMP:MGI.
 GO:0035019; P:somatic stem cell maintenance; IMP:MGI.
 GO:0001756; P:somitogenesis; TAS:BHF-UCL.
 GO:0003222; P:ventricular trabecula myocardium morphogenesis; IMP:BHF-UCL. 
Interpro
 IPR015350; Beta-trefoil_DNA-bd_dom.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR015351; LAG1_DNA-bd.
 IPR008967; p53-like_TF_DNA-bd. 
Pfam
 PF09270; BTD
 PF09271; LAG1-DNAbind
 PF01833; TIG 
SMART
  
PROSITE
  
PRINTS