CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001822
UniProt Accession
Genbank Protein ID
 M21197 
Genbank Nucleotide ID
Protein Name
 Citrate synthase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 CS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Sus scrofa (Pig) 
NCBI Taxa ID
 9823 
Lysine Modification
Position
Peptide
Type
References
76YGGMRGMKGLVYETSsuccinylation[1]
395LLEQGKAKNPWPNVDmethylation[2]
Reference
 [1] Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
 Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H.
 Science. 2011 Nov 11;334(6057):806-9. [PMID: 22076378]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 
Functional Description
  
Sequence Annotation
 ACT_SITE 301 301
 ACT_SITE 347 347
 ACT_SITE 402 402
 MOD_RES 76 76 N6-acetyllysine; alternate (By
 MOD_RES 76 76 N6-succinyllysine; alternate (By
 MOD_RES 327 327 N6-acetyllysine (By similarity).
 MOD_RES 375 375 N6-acetyllysine (By similarity).
 MOD_RES 382 382 N6-acetyllysine (By similarity).
 MOD_RES 393 393 N6-acetyllysine (By similarity).
 MOD_RES 395 395 N6,N6,N6-trimethyllysine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Methylation; Mitochondrion; Reference proteome; Transferase; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 464 AA 
Protein Sequence
MALLTAAARL FGAKNASCLV LAARHASASS TNLKDILADL IPKEQARIKT FRQQHGNTVV 60
GQITVDMMYG GMRGMKGLVY ETSVLDPDEG IRFRGYSIPE CQKMLPKAKG GEEPLPEGLF 120
WLLVTGQIPT EEQVSWLSKE WAKRAALPSH VVTMLDNFPT NLHPMSQLSA AITALNSESN 180
FARAYAEGIH RTKYWELIYE DCMDLIAKLP CVAAKIYRNL YREGSSIGAI DSKLDWSHNF 240
TNMLGYTDAQ FTELMRLYLT IHSDHEGGNV SAHTSHLVGS ALSDPYLSFA AAMNGLAGPL 300
HGLANQEVLV WLTQLQKEVG KDVSDEKLRD YIWNTLNSGR VVPGYGHAVL RKTDPRYTCQ 360
REFALKHLPH DPMFKLVAQL YKIVPNVLLE QGKAKNPWPN VDAHSGVLLQ YYGMTEMNYY 420
TVLFGVSRAL GVLAQLIWSR ALGFPLERPK SMSTDGLIKL VDSK 464 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
 GO:0004108; F:citrate (Si)-synthase activity; ISS:UniProtKB.
 GO:0005975; P:carbohydrate metabolic process; ISS:UniProtKB.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. 
Interpro
 IPR016142; Citrate_synth-like_lrg_a-sub.
 IPR002020; Citrate_synthase-like.
 IPR016141; Citrate_synthase-like_core.
 IPR019810; Citrate_synthase_AS.
 IPR010109; Citrate_synthase_euk. 
Pfam
 PF00285; Citrate_synt 
SMART
  
PROSITE
 PS00480; CITRATE_SYNTHASE 
PRINTS
 PR00143; CITRTSNTHASE.