UniProt Accession

 RPAC1_YEAST; P07703; D6W4A9 

Genbank Protein ID

 M15499; U32445; BK006949 

Genbank Nucleotide ID

 AAA34999.1; AAB68080.1; DAA11525.1 

Protein Name

 DNA-directed RNA polymerases I and III subunit RPAC1 

Protein Synonyms/Alias

 RNA polymerases I and III subunit AC1; C37; DNA-directed RNA polymerases I and III 40 kDa polypeptide; AC40; C40 

Gene Name

 RPC40 

Gene Synonyms/Alias

 RPA5; RPC5; YPR110C; P8283.18 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
25	TDFPGFSKDAENEWN	acetylation	[1]
25	TDFPGFSKDAENEWN	ubiquitination	[2]
148	TRNPDAPKGSTDPKE	ubiquitination	[2]
268	GSDEAYVKDARKDTV	ubiquitination	[2]
329	KNKAEYLKNCPITQ*	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). 

Sequence Annotation

 MOD_RES 17 17 Phosphoserine.  

Keyword

 Complete proteome; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0005736; C:DNA-directed RNA polymerase I complex; IDA:SGD.
 GO:0005666; C:DNA-directed RNA polymerase III complex; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0006360; P:transcription from RNA polymerase I promoter; IDA:SGD.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IDA:SGD. 

Interpro

 IPR001514; DNA-dir_RNA_pol_30-40kDasu_CS.
 IPR011261; DNA-dir_RNA_pol_dimersation.
 IPR011262; DNA-dir_RNA_pol_insert.
 IPR009025; DNA-dir_RNA_pol_RBP11-like.
 IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3. 

Pfam

 PF01000; RNA_pol_A_bac
 PF01193; RNA_pol_L 

SMART

 SM00662; RPOLD 

PROSITE

 PS00446; RNA_POL_D_30KD 

PRINTS