| Tag | Content |
|---|
| CPLM ID | CPLM-016163 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polypeptide N-acetylgalactosaminyltransferase 10 |
Protein Synonyms/Alias | Polypeptide GalNAc transferase 10; GalNAc-T10; pp-GaNTase 10; Protein-UDP acetylgalactosaminyltransferase 10; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 |
Gene Name | GALNT10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 425 | GDVAVQKKLRSSLNC | ubiquitination | [1] | | 475 | TGLCADTKHGALGSP | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates. |
Sequence Annotation | DOMAIN 458 590 Ricin B-type lectin.
REGION 144 253 Catalytic subdomain A.
REGION 311 373 Catalytic subdomain B.
REGION 373 384 Flexible loop.
METAL 237 237 Manganese.
METAL 239 239 Manganese.
METAL 370 370 Manganese.
BINDING 185 185 Substrate.
BINDING 237 237 Substrate.
CARBOHYD 124 124 N-linked (GlcNAc...).
CARBOHYD 146 146 N-linked (GlcNAc...).
CARBOHYD 593 593 N-linked (GlcNAc...).
DISULFID 135 365
DISULFID 356 432
DISULFID 471 488
DISULFID 523 538
DISULFID 563 578 |
Keyword | 3D-structure; Alternative splicing; Calcium; Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Lectin; Manganese; Membrane; Metal-binding; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 603 AA |
Protein Sequence | MRRKEKRLLQ AVALVLAALV LLPNVGLWAL YRERQPDGTP GGSGAAVAPA AGQGSHSRQK 60
KTFFLGDGQK LKDWHDKEAI RRDAQRVGNG EQGRPYPMTD AERVDQAYRE NGFNIYVSDK 120
ISLNRSLPDI RHPNCNSKRY LETLPNTSII IPFHNEGWSS LLRTVHSVLN RSPPELVAEI 180
VLVDDFSDRE HLKKPLEDYM ALFPSVRILR TKKREGLIRT RMLGASVATG DVITFLDSHC 240
EANVNWLPPL LDRIARNRKT IVCPMIDVID HDDFRYETQA GDAMRGAFDW EMYYKRIPIP 300
PELQKADPSD PFESPVMAGG LFAVDRKWFW ELGGYDPGLE IWGGEQYEIS FKVWMCGGRM 360
EDIPCSRVGH IYRKYVPYKV PAGVSLARNL KRVAEVWMDE YAEYIYQRRP EYRHLSAGDV 420
AVQKKLRSSL NCKSFKWFMT KIAWDLPKFY PPVEPPAAAW GEIRNVGTGL CADTKHGALG 480
SPLRLEGCVR GRGEAAWNNM QVFTFTWRED IRPGDPQHTK KFCFDAISHT SPVTLYDCHS 540
MKGNQLWKYR KDKTLYHPVS GSCMDCSESD HRIFMNTCNP SSLTQQWLFE HTNSTVLEKF 600
NRN 603 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:EC. GO:0016266; P:O-glycan processing; TAS:Reactome. GO:0043687; P:post-translational protein modification; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
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PRINTS | |