CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031338
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 
Protein Synonyms/Alias
 cDNA FLJ53227, highly similar to Peptidylprolyl isomerase domain and WDrepeat-containing protein 1 (EC 5.2.1.8) 
Gene Name
 PPWD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
64QPLHIFDKLHTSPLTubiquitination[1, 2]
122TDLYEFAKCKAYPTSubiquitination[1]
196AVERELEKVDAVRLIubiquitination[2]
238RCVRILGKQENIRVMubiquitination[1]
288TIVCTSFKKNRFYMFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 490 AA 
Protein Sequence
MKVFDVVNFD MINMLKLGYF PGQCEWIYCP GDAISSVAAS EKSTGKIFIY DGRGDNQPLH 60
IFDKLHTSPL TQIRLNPVYK AVVSSDKSGM IEYWTGPPHE YKFPKNVNWE YKTDTDLYEF 120
AKCKAYPTSV CFSPDGKKIA TIGSDRKVRI FRFVTGKLMR VFDESLSMFT ELQQMRQQLP 180
DMEFGRRMAV ERELEKVDAV RLINIVFDET GHFVLYGTML GIKVINVETN RCVRILGKQE 240
NIRVMQLALF QGIAKKHRAA TTIEMKASEN PVLQNIQADP TIVCTSFKKN RFYMFTKREP 300
EDTKSADSDR DVFNEKPSKE EVMAATQAEG PKRVSDSAII HTSMGDIHTK LFPVECPKTV 360
ENFCVHSRNG YYNGHTFHRI IKGFMIQTGD PTGTGMGGES IWGGEFEDEF HSTLRHDRPY 420
TLSMANAGSN TNGSQFFITV VPTPWLDNKH TVFGRVTKGM EVVQRISNVK VNPKTDKPYE 480
DVSIINITVK 490 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC. 
Interpro
 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00160; Pro_isomerase
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50072; CSA_PPIASE_2 
PRINTS
 PR00153; CSAPPISMRASE.