| Tag | Content |
|---|
| CPLM ID | CPLM-022742 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synaptotagmin-11 |
Protein Synonyms/Alias | Synaptotagmin XI; SytXI |
Gene Name | Syt11 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 54 | KHKTPPYKFIHMLKG | ubiquitination | [1] | | 60 | YKFIHMLKGISIYPE | ubiquitination | [1] | | 72 | YPETLSNKKKIIKVR | ubiquitination | [1] | | 73 | PETLSNKKKIIKVRR | ubiquitination | [1] | | 107 | SGLLSHDKDPRGPSP | ubiquitination | [1] | | 124 | CMDQLPIKRDYGEEL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). |
Sequence Annotation | DOMAIN 173 261 C2 1.
DOMAIN 303 396 C2 2.
METAL 187 187 Calcium 1 (By similarity).
METAL 187 187 Calcium 2 (By similarity).
METAL 194 194 Calcium 1 (By similarity).
METAL 248 248 Calcium 1; via carbonyl oxygen (By
METAL 249 249 Calcium 1 (By similarity).
METAL 249 249 Calcium 2 (By similarity).
METAL 249 249 Calcium 3 (By similarity).
METAL 252 252 Calcium 3 (By similarity).
METAL 255 255 Calcium 2 (By similarity).
METAL 255 255 Calcium 3 (By similarity). |
Keyword | Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Membrane; Metal-binding; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 430 AA |
Protein Sequence | MAEITNIRPS FDVSPVAAGL IGASVLVVCV SVTVFVWTCC HQQAEKKHKT PPYKFIHMLK 60
GISIYPETLS NKKKIIKVRR DKDGPRRESG RGNLLINAES GLLSHDKDPR GPSPASCMDQ 120
LPIKRDYGEE LRSPMTSLTP GESKATSPSS PEEDVMLGSL TFSVDYNFPK KALVVTIQEA 180
HGLPVMDDQT QGSDPYIKMT ILPDKRHRVK TRVLRKTLDP VFDETFTFYG IPYSQLQDLV 240
LHFLVLSFDR FSRDDVIGEV MVPLAGVDPS TGKVQLTRDI IKRNIQKCIS RGELQVSLSY 300
QPVAQRMTVV VLKARHLPKM DITGLSGNPY VKVNVYYGRK RIAKKKTHVK KCTLNPVFNE 360
SFIYDIPTDL LPDISIEFLV IDFDRTTKNE VVGRLILGAH SVTTSGAEHW REVCESPRKP 420
IAKWHSLSEY 430 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005887; C:integral to plasma membrane; IDA:MGI. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005215; F:transporter activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |