CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027705
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Map3k7 protein 
Protein Synonyms/Alias
 Mitogen activated protein kinase kinase kinase 7, isoform CRA_b; Mitogen-activated protein kinase kinase kinase 7 
Gene Name
 Map3k7 
Gene Synonyms/Alias
 mCG_121930 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
590TYYQQCKKQLEVIRSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 606 AA 
Protein Sequence
MSTASAASSS SSSSASEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 60
AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 120
PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 180
DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 240
WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 300
PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 360
SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIV ATAAYSKPKR GHRKTASFGN 420
ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPARSHP 480
WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI 540
ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ 600
KRQGTS 606 
Gene Ontology
 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IEA:Compara.
 GO:0008385; C:IkappaB kinase complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004708; F:MAP kinase kinase activity; IDA:MGI.
 GO:0004709; F:MAP kinase kinase kinase activity; IEA:Compara.
 GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0043966; P:histone H3 acetylation; IEA:Compara.
 GO:0007252; P:I-kappaB phosphorylation; IGI:MGI.
 GO:0007254; P:JNK cascade; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0001841; P:neural tube formation; IMP:MGI.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IGI:MGI.
 GO:0032743; P:positive regulation of interleukin-2 production; IEA:Compara.
 GO:0046330; P:positive regulation of JNK cascade; IGI:MGI.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0002726; P:positive regulation of T cell cytokine production; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR017421; MAPKKK7.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF07714; Pkinase_Tyr 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS
 PR00109; TYRKINASE.