CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002843
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synapsin-1 
Protein Synonyms/Alias
 Synapsin I 
Gene Name
 Syn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
179VKVVRSLKPDFVLIRacetylation[1]
238QMVRLHKKLGTEEFPacetylation[1]
238QMVRLHKKLGTEEFPubiquitination[2]
311AEPFIDAKYDVRVQKacetylation[1]
311AEPFIDAKYDVRVQKubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. 
Sequence Annotation
 REGION 1 28 A.
 REGION 29 112 B; linker.
 REGION 113 420 C; actin-binding and synaptic-vesicle
 REGION 421 655 D; Pro-rich linker.
 REGION 656 704 E.
 MOD_RES 9 9 Phosphoserine; by CaMK1 and PKA;
 MOD_RES 9 9 Phosphoserine; by PKA and CaMK1;
 MOD_RES 62 62 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine (By similarity).
 MOD_RES 312 312 Phosphotyrosine (By similarity).
 MOD_RES 337 337 Phosphothreonine (By similarity).
 MOD_RES 425 425 Phosphoserine (By similarity).
 MOD_RES 508 508 Phosphoserine (By similarity).
 MOD_RES 510 510 Phosphothreonine (By similarity).
 MOD_RES 518 518 Phosphoserine (By similarity).
 MOD_RES 549 549 Phosphoserine (By similarity).
 MOD_RES 551 551 Phosphoserine; by PDPK1 (By similarity).
 MOD_RES 566 566 Phosphoserine; by CaMK2.
 MOD_RES 603 603 Phosphoserine; by CaMK2.
 MOD_RES 664 664 Phosphoserine (By similarity).
 MOD_RES 703 703 Phosphoserine (By similarity).
 CARBOHYD 55 55 O-linked (GlcNAc).
 CARBOHYD 56 56 O-linked (GlcNAc) (Probable).
 CARBOHYD 87 87 O-linked (GlcNAc).
 CARBOHYD 96 96 O-linked (GlcNAc).
 CARBOHYD 103 103 O-linked (GlcNAc) (Probable).
 CARBOHYD 261 261 O-linked (GlcNAc).
 CARBOHYD 430 430 O-linked (GlcNAc).
 CARBOHYD 516 516 O-linked (GlcNAc).
 CARBOHYD 524 524 O-linked (GlcNAc).
 CARBOHYD 562 562 O-linked (GlcNAc).
 CARBOHYD 576 576 O-linked (GlcNAc).  
Keyword
 3D-structure; Actin-binding; Alternative splicing; Cell junction; Complete proteome; Direct protein sequencing; Glycoprotein; Golgi apparatus; Phosphoprotein; Reference proteome; Repeat; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 704 AA 
Protein Sequence
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPSAASP GATPGSAAAS AERASTAAPV 60
ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG GGSGGAGRGG AAARVLLVID 120
EPHTDWAKYF KGKKIHGEID IKVEQAEFSD LNLVAHANGG FSVDMEVLRN GVKVVRSLKP 180
DFVLIRQHAF SMARNGDYRS LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG 240
TEEFPLIDQT FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT 300
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS DRYKLWVDTC 360
SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD EDKQLIVELV VNKMTQALPR 420
QRDASPGRGS HSQTPSPGAL PLGRQTSQQP AGPPAQQRPP PQGGPPQPGP GPQRQGPPLQ 480
QRPPPQGQQH LSGLGPPAGS PLPQRLPSPT AAPQQSASQA TPMTQGQGRQ SRPVAGGPGA 540
PPAARPPASP SPQRQAGPPQ ATRQASISGP APPKVSGASP GGQQRQGPPQ KPPGPAGPIR 600
QASQAGPGPR TGPPTTQQPR PSGPGPAGRP TKPQLAQKPS QDVPPPIIAA AGGPPHPQLN 660
KSQSLTNAFN LPEPAPPRPS LSQDEVKAET IRSLRKSFAS LFSD 704 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0030425; C:dendrite; IDA:BHF-UCL.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0048786; C:presynaptic active zone; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IDA:UniProtKB.
 GO:0030672; C:synaptic vesicle membrane; IEA:Compara.
 GO:0000795; C:synaptonemal complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0007269; P:neurotransmitter secretion; TAS:RGD. 
Interpro
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR016185; PreATP-grasp_dom.
 IPR001359; Synapsin.
 IPR020898; Synapsin_ATP-bd_dom.
 IPR019735; Synapsin_CS.
 IPR019736; Synapsin_P_site.
 IPR020897; Synapsin_pre-ATP-grasp_dom. 
Pfam
 PF02078; Synapsin
 PF02750; Synapsin_C
 PF10581; Synapsin_N 
SMART
  
PROSITE
 PS00415; SYNAPSIN_1
 PS00416; SYNAPSIN_2 
PRINTS
 PR01368; SYNAPSIN.