CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CCAAT/enhancer-binding protein beta 
Protein Synonyms/Alias
 C/EBP beta; C/EBP-related protein 2; Interleukin-6-dependent-binding protein; IL-6DBP; Liver-enriched transcriptional activator; LAP; Silencer factor B; SF-B 
Gene Name
 Cebpb 
Gene Synonyms/Alias
 Crp2; Sfb 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
39DCLAYGAKAARAAPRmethylation[1]
99FADDYGAKPSKKPSDmethylation[2]
102DYGAKPSKKPSDYGYmethylation[2]
134PPPPAALKAEPGFEPmethylation[2]
145GFEPADCKRADDAPAmethylation[2]
212GPPAAPAKAKAKKAVmethylation[2]
267AENERLQKKVEQLSRmethylation[2]
284STLRNLFKQLPEPLLmethylation[2]
Reference
 [1] G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.
 Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ, Leutz A.
 J Biol Chem. 2008 Sep 26;283(39):26357-63. [PMID: 18647749]
 [2] Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.
 Leutz A, Pless O, Lappe M, Dittmar G, Kowenz-Leutz E.
 Transcription. 2011 Jan-Feb;2(1):3-8. [PMID: 21326902] 
Functional Description
 Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity). 
Sequence Annotation
 DOMAIN 223 286 bZIP.
 REGION 1 22 Required for Lys-174 sumoylation (By
 REGION 227 247 Basic motif (By similarity).
 REGION 249 256 Leucine-zipper (By similarity).
 MOD_RES 189 189 Phosphothreonine; by RPS6KA1 (By
 CROSSLNK 134 134 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Activator; Complete proteome; Differentiation; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MHRLLAWDAA CLPPPPAAFR PMEVANFYYE PDCLAYGAKA ARAAPRAPAA EPAIGEHERA 60
IDFSPYLEPL APAAADFAAP APAHHDFLSD LFADDYGAKP SKKPSDYGYV SLGRAGAKAA 120
PPACFPPPPP AALKAEPGFE PADCKRADDA PAMAAGFPFA LRAYLGYQAT PSGSSGSLST 180
SSSSSPPGTP SPADAKAAPA ACFAGPPAAP AKAKAKKAVD KLSDEYKMRR ERNNIAVRKS 240
RDKAKMRNLE TQHKVLELTA ENERLQKKVE QLSRELSTLR NLFKQLPEPL LASAGHC 297 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0016363; C:nuclear matrix; IDA:RGD.
 GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0071230; P:cellular response to amino acid stimulus; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Compara.
 GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0045408; P:regulation of interleukin-6 biosynthetic process; IEA:Compara.
 GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara. 
Interpro
 IPR004827; bZIP.
 IPR016468; CCAAT/enhancer-binding. 
Pfam
 PF07716; bZIP_2 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS