UniProt Accession

 NR3L1_HUMAN; Q68D85; Q7Z3M6 

Genbank Protein ID

 BX537685; CR749521; AC124798; BC136800; BC136797 

Genbank Nucleotide ID

 CAD97811.1; CAH18335.1 

Protein Name

 Natural cytotoxicity triggering receptor 3 ligand 1 

Protein Synonyms/Alias

 B7 homolog 6; B7-H6 

Gene Name

 NCR3LG1 

Gene Synonyms/Alias

 B7H6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	WKSLTFDKEVKVFEF	ubiquitination	[1]
101	IVSPWRLKSGDASLR	ubiquitination	[2]
183	TWEKQTQKFPHPIEI	ubiquitination	[1]
314	SFDTQTLKKEHLIFF	ubiquitination	[2]
396	LLTVTSGKSIDDNST	ubiquitination	[1]
404	SIDDNSTKSEKQTPR	ubiquitination	[2]
407	DNSTKSEKQTPREHS	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Triggers NCR3-dependent natural killer cell activation. 

Sequence Annotation

 DOMAIN 27 138 Ig-like V-type.
 DOMAIN 143 244 Ig-like C1-type.
 REGION 59 62 Interaction with NCR3.
 REGION 127 130 Interaction with NCR3.
 REGION 291 429 Retroviral-Gag-like.
 CARBOHYD 43 43 N-linked (GlcNAc...).
 CARBOHYD 57 57 N-linked (GlcNAc...).
 CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...).
 CARBOHYD 216 216 N-linked (GlcNAc...) (Potential).
 CARBOHYD 242 242 N-linked (GlcNAc...).
 CARBOHYD 260 260 N-linked (GlcNAc...) (Potential).
 DISULFID 48 122
 DISULFID 163 228  

Keyword

 3D-structure; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 454 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0019028; C:viral capsid; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 

Interpro

 IPR000840; G_retro_matrix_N.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR003599; Ig_sub.
 IPR010999; Retrovr_matrix_N. 

Pfam

 PF07654; C1-set
 PF01140; Gag_MA 

SMART

 SM00409; IG
 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS