CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008940
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oxysterols receptor LXR-beta 
Protein Synonyms/Alias
 Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor 
Gene Name
 NR1H2 
Gene Synonyms/Alias
 LXRB; NER; UNR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31PSSSPTVKEEGPEPWsumoylation[1]
247RSFSDQPKVTPWPLGubiquitination[2]
409LLSYTRIKRPQDQLRsumoylation[3]
447ALRLQDKKLPPLLSEsumoylation[3]
447ALRLQDKKLPPLLSEubiquitination[2]
Reference
 [1] Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes.
 Lee JH, Park SM, Kim OS, Lee CS, Woo JH, Park SJ, Joe EH, Jou I.
 Mol Cell. 2009 Sep 24;35(6):806-17. [PMID: 19782030]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.
 Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK.
 Mol Cell. 2007 Jan 12;25(1):57-70. [PMID: 17218271] 
Functional Description
 Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). 
Sequence Annotation
 DNA_BIND 84 161 Nuclear receptor.
 ZN_FING 87 107 NR C4-type.
 ZN_FING 125 149 NR C4-type.
 REGION 230 460 Ligand-binding (Potential).  
Keyword
 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 460 AA 
Protein Sequence
MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW 60
VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA 120
RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQESQSQ 180
SQSPVGPQGS SSSASGPGAS PGGSEAGSQG SGEGEGVQLT AAQELMIQQL VAAQLQCNKR 240
SFSDQPKVTP WPLGADPQSR DARQQRFAHF TELAIISVQE IVDFAKQVPG FLQLGREDQI 300
ALLKASTIEI MLLETARRYN HETECITFLK DFTYSKDDFH RAGLQVEFIN PIFEFSRAMR 360
RLGLDDAEYA LLIAINIFSA DRPNVQEPGR VEALQQPYVE ALLSYTRIKR PQDQLRFPRM 420
LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE 460 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0001133; F:sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0044255; P:cellular lipid metabolic process; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0010887; P:negative regulation of cholesterol storage; IMP:BHF-UCL.
 GO:0060336; P:negative regulation of interferon-gamma-mediated signaling pathway; NAS:BHF-UCL.
 GO:0032369; P:negative regulation of lipid transport; IMP:BHF-UCL.
 GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; IC:BHF-UCL.
 GO:0048550; P:negative regulation of pinocytosis; IMP:BHF-UCL.
 GO:0045861; P:negative regulation of proteolysis; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:HGNC.
 GO:0032270; P:positive regulation of cellular protein metabolic process; IMP:BHF-UCL.
 GO:0010875; P:positive regulation of cholesterol efflux; IMP:BHF-UCL.
 GO:0045723; P:positive regulation of fatty acid biosynthetic process; IMP:BHF-UCL.
 GO:0090108; P:positive regulation of high-density lipoprotein particle assembly; IEA:Compara.
 GO:0010884; P:positive regulation of lipid storage; IEA:Compara.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IMP:BHF-UCL.
 GO:0090187; P:positive regulation of pancreatic juice secretion; IEA:Compara.
 GO:0090340; P:positive regulation of secretion of lysosomal enzymes; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IMP:BHF-UCL.
 GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 
Interpro
 IPR023257; Liver_X_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR02034; LIVERXRECPTR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.