Tag | Content |
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CPLM ID | CPLM-007361 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1 |
Protein Synonyms/Alias | Synthetic lethal with MSS4 protein 1; TORC2 effector protein SLM1 |
Gene Name | SLM1 |
Gene Synonyms/Alias | LIT2; YIL105C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
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143 | NGKQLQGKNSLTNTS | ubiquitination | [1] |
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Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. |
Sequence Annotation | DOMAIN 468 581 PH. MOTIF 673 678 PXIXIT-like, required for interaction MOD_RES 145 145 Phosphoserine. MOD_RES 150 150 Phosphoserine. MOD_RES 153 153 Phosphoserine. |
Keyword | 3D-structure; Cell membrane; Coiled coil; Complete proteome; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 686 AA |
Protein Sequence | MSKNNTMTSA VSDMLSQQQL NLQHLHNLQQ HTRSMTSADH ANVLQQQQQQ QQQQQQQQQQ 60 QQQSASFQNG SLTSDINQQS YLNGQPVPST SNSTFQNNRT LTMNSGGLQG IISNGSPNID 120 SNTNVTIAVP DPNNNNGKQL QGKNSLTNTS ILSRARSSLQ RQRLAQQQQQ QQDPRSPLVI 180 LVPTAAQPTD ILAARFSAWR NVIKSVIVYL TEIASIQDEI VRQQLRLSHA VQFPFFSIEN 240 QYQPSSQEDK SVQKFFLPLG NGSIQDLPTI LNQYHESLAS SASKASRELT NDVIPRLEDL 300 RRDLIVKIKE IKSLQSDFKN SCSKELQQTK QAMKQFQESL KDARYSVPKQ DPFLTKLALD 360 RQIKKQLQEE NFLHEAFDNL ETSGAELEKI VVMEIQNSLT IYARLLGQEA QLVFDILISK 420 LDSGFFNVDP QFEWDNFISR DPNFLLPNLP MRTFKEIVYK YQFDPLTYEI KSGFLERRSK 480 FLKSYSKGYY VLTPNFLHEF KTADRKKDLV PVMSLALSEC TVTEHSRKNS TSSPNSTGSD 540 AKFVLHAKQN GIIRRGHNWV FKADSYESMM SWFDNLKILT STSNIQDKYK FITQKLNLNS 600 DGKPKLTNNH TSINKYQLSN ANSTMVENDE NDDINSNYVG STVTPKLDNQ TNTNTSMSSL 660 PDTNDSELQD QVPNIYIQTP INDFKS 686 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:SGD. GO:0046625; F:sphingolipid binding; IDA:SGD. GO:0051017; P:actin filament bundle assembly; IGI:SGD. GO:0070941; P:eisosome assembly; IGI:SGD. GO:0016197; P:endosomal transport; IGI:SGD. GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IPI:SGD. GO:0001558; P:regulation of cell growth; IGI:SGD. GO:0031929; P:TOR signaling cascade; IPI:SGD. |
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