UniProt Accession

 SPS19_YEAST; P32573; D6W0Y6 

Genbank Protein ID

 X78898; Z71479; AY693119; M90351; BK006947 

Genbank Nucleotide ID

 CAA55506.1; CAA96103.1; AAT93138.1; AAA62403.1; DAA10352.1 

Protein Name

 Peroxisomal 2,4-dienoyl-CoA reductase SPS19 

Protein Synonyms/Alias

 Sporulation-specific protein SPX19 

Gene Name

 SPS19 

Gene Synonyms/Alias

 SPX19; YNL202W; N1362 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
66	ERTEQAAKGISQLAK	ubiquitination	[1]
188	AGIDALAKNLAVELG	ubiquitination	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate. 

Sequence Annotation

 NP_BIND 29 53 NADP (By similarity).
 MOTIF 290 292 Microbody targeting signal (Potential).  

Keyword

 Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Peroxisome; Reference proteome; Sporulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0005782; C:peroxisomal matrix; IDA:SGD.
 GO:0008670; F:2,4-dienoyl-CoA reductase (NADPH) activity; IDA:SGD.
 GO:0030437; P:ascospore formation; IEP:SGD.
 GO:0009062; P:fatty acid catabolic process; IDA:SGD. 

Interpro

 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.