CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006038
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neural cell adhesion molecule L1 
Protein Synonyms/Alias
 N-CAM-L1; NCAM-L1; CD171 
Gene Name
 L1CAM 
Gene Synonyms/Alias
 CAML1; MIC5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
530GPRSTIEKKGSRVTFacetylation[1]
998FQLQATTKEGPGEAIubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. 
Sequence Annotation
 DOMAIN 35 125 Ig-like C2-type 1.
 DOMAIN 139 226 Ig-like C2-type 2.
 DOMAIN 240 328 Ig-like C2-type 3.
 DOMAIN 333 420 Ig-like C2-type 4.
 DOMAIN 425 507 Ig-like C2-type 5.
 DOMAIN 518 607 Ig-like C2-type 6.
 DOMAIN 612 707 Fibronectin type-III 1.
 DOMAIN 714 807 Fibronectin type-III 2.
 DOMAIN 812 913 Fibronectin type-III 3.
 DOMAIN 914 1011 Fibronectin type-III 4.
 DOMAIN 1016 1108 Fibronectin type-III 5.
 MOTIF 554 556 Cell attachment site (Potential).
 MOD_RES 1163 1163 Phosphoserine.
 MOD_RES 1181 1181 Phosphoserine; by CaMK2.
 MOD_RES 1194 1194 Phosphoserine.
 MOD_RES 1247 1247 Phosphothreonine (By similarity).
 MOD_RES 1248 1248 Phosphoserine.
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).
 CARBOHYD 294 294 N-linked (GlcNAc...) (Potential).
 CARBOHYD 433 433 N-linked (GlcNAc...) (Potential).
 CARBOHYD 479 479 N-linked (GlcNAc...) (Potential).
 CARBOHYD 490 490 N-linked (GlcNAc...) (Potential).
 CARBOHYD 505 505 N-linked (GlcNAc...) (Potential).
 CARBOHYD 588 588 N-linked (GlcNAc...) (Potential).
 CARBOHYD 671 671 N-linked (GlcNAc...).
 CARBOHYD 726 726 N-linked (GlcNAc...) (Potential).
 CARBOHYD 777 777 N-linked (GlcNAc...) (Potential).
 CARBOHYD 825 825 N-linked (GlcNAc...) (Potential).
 CARBOHYD 849 849 N-linked (GlcNAc...) (Potential).
 CARBOHYD 876 876 N-linked (GlcNAc...) (Potential).
 CARBOHYD 979 979 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1022 1022 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1030 1030 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1071 1071 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1105 1105 N-linked (GlcNAc...) (Potential).
 DISULFID 57 114 By similarity.
 DISULFID 158 209 By similarity.
 DISULFID 264 312 By similarity.
 DISULFID 354 404 By similarity.
 DISULFID 448 497 By similarity.
 DISULFID 539 591 By similarity.  
Keyword
 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hereditary spastic paraplegia; Hirschsprung disease; Immunoglobulin domain; Membrane; Mental retardation; Neurodegeneration; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1257 AA 
Protein Sequence
MVVALRYVWP LLLCSPCLLI QIPEEYEGHH VMEPPVITEQ SPRRLVVFPT DDISLKCEAS 60
GKPEVQFRWT RDGVHFKPKE ELGVTVYQSP HSGSFTITGN NSNFAQRFQG IYRCFASNKL 120
GTAMSHEIRL MAEGAPKWPK ETVKPVEVEE GESVVLPCNP PPSAEPLRIY WMNSKILHIK 180
QDERVTMGQN GNLYFANVLT SDNHSDYICH AHFPGTRTII QKEPIDLRVK ATNSMIDRKP 240
RLLFPTNSSS HLVALQGQPL VLECIAEGFP TPTIKWLRPS GPMPADRVTY QNHNKTLQLL 300
KVGEEDDGEY RCLAENSLGS ARHAYYVTVE AAPYWLHKPQ SHLYGPGETA RLDCQVQGRP 360
QPEVTWRING IPVEELAKDQ KYRIQRGALI LSNVQPSDTM VTQCEARNRH GLLLANAYIY 420
VVQLPAKILT ADNQTYMAVQ GSTAYLLCKA FGAPVPSVQW LDEDGTTVLQ DERFFPYANG 480
TLGIRDLQAN DTGRYFCLAA NDQNNVTIMA NLKVKDATQI TQGPRSTIEK KGSRVTFTCQ 540
ASFDPSLQPS ITWRGDGRDL QELGDSDKYF IEDGRLVIHS LDYSDQGNYS CVASTELDVV 600
ESRAQLLVVG SPGPVPRLVL SDLHLLTQSQ VRVSWSPAED HNAPIEKYDI EFEDKEMAPE 660
KWYSLGKVPG NQTSTTLKLS PYVHYTFRVT AINKYGPGEP SPVSETVVTP EAAPEKNPVD 720
VKGEGNETTN MVITWKPLRW MDWNAPQVQY RVQWRPQGTR GPWQEQIVSD PFLVVSNTST 780
FVPYEIKVQA VNSQGKGPEP QVTIGYSGED YPQAIPELEG IEILNSSAVL VKWRPVDLAQ 840
VKGHLRGYNV TYWREGSQRK HSKRHIHKDH VVVPANTTSV ILSGLRPYSS YHLEVQAFNG 900
RGSGPASEFT FSTPEGVPGH PEALHLECQS NTSLLLRWQP PLSHNGVLTG YVLSYHPLDE 960
GGKGQLSFNL RDPELRTHNL TDLSPHLRYR FQLQATTKEG PGEAIVREGG TMALSGISDF 1020
GNISATAGEN YSVVSWVPKE GQCNFRFHIL FKALGEEKGG ASLSPQYVSY NQSSYTQWDL 1080
QPDTDYEIHL FKERMFRHQM AVKTNGTGRV RLPPAGFATE GWFIGFVSAI ILLLLVLLIL 1140
CFIKRSKGGK YSVKDKEDTQ VDSEARPMKD ETFGEYRSLE SDNEEKAFGS SQPSLNGDIK 1200
PLGSDDSLAD YGGSVDVQFN EDGSFIGQYS GKKEKEAAGG NDSSGATSPI NPAVALE 1257 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0043195; C:terminal bouton; IEA:Compara.
 GO:0033691; F:sialic acid binding; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:Compara.
 GO:0033631; P:cell-cell adhesion mediated by integrin; IEA:Compara.
 GO:0007157; P:heterophilic cell-cell adhesion; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; IEA:Compara.
 GO:0034109; P:homotypic cell-cell adhesion; IEA:Compara.
 GO:0007159; P:leukocyte cell-cell adhesion; IEA:Compara.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Compara.
 GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Compara. 
Interpro
 IPR026966; Fibronectin_III_C.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF13882; Bravo_FIGEY
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS