CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022134
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Structural maintenance of chromosomes protein 4 
Protein Synonyms/Alias
 SMC protein 4; SMC-4; Chromosome-associated polypeptide C; hCAP-C; XCAP-C homolog 
Gene Name
 SMC4 
Gene Synonyms/Alias
 CAPC; SMC4L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
607LDAIIQEKKSGRIPGubiquitination[1]
1209DRLIGIYKTYNITKSubiquitination[1]
1215YKTYNITKSVAVNPKubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. 
Sequence Annotation
 NP_BIND 113 120 ATP (Potential).
 REGION 589 766 Flexible hinge.
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 39 39 Phosphothreonine.
 MOD_RES 41 41 Phosphoserine.
 MOD_RES 50 50 Phosphoserine.
 MOD_RES 143 143 Phosphoserine.
 MOD_RES 679 679 N6-acetyllysine.
 MOD_RES 1056 1056 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; ATP-binding; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; Cytoplasm; DNA condensation; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1288 AA 
Protein Sequence
MPRKGTQPST ARRREEGPPP PSPDGASSDA EPEPPSGRTE SPATAAETAS EELDNRSLEE 60
ILNSIPPPPP PAMTNEAGAP RLMITHIVNQ NFKSYAGEKI LGPFHKRFSC IIGPNGSGKS 120
NVIDSMLFVF GYRAQKIRSK KLSVLIHNSD EHKDIQSCTV EVHFQKIIDK EGDDYEVIPN 180
SNFYVSRTAC RDNTSVYHIS GKKKTFKDVG NLLRSHGIDL DHNRFLILQG EVEQIAMMKP 240
KGQTEHDEGM LEYLEDIIGC GRLNEPIKVL CRRVEILNEH RGEKLNRVKM VEKEKDALEG 300
EKNIAIEFLT LENEIFRKKN HVCQYYIYEL QKRIAEMETQ KEKIHEDTKE INEKSNILSN 360
EMKAKNKDVK DTEKKLNKIT KFIEENKEKF TQLDLEDVQV REKLKHATSK AKKLEKQLQK 420
DKEKVEEFKS IPAKSNNIIN ETTTRNNALE KEKEKEEKKL KEVMDSLKQE TQGLQKEKES 480
REKELMGFSK SVNEARSKMD VAQSELDIYL SRHNTAVSQL TKAKEALIAA SETLKERKAA 540
IRDIEGKLPQ TEQELKEKEK ELQKLTQEET NFKSLVHDLF QKVEEAKSSL AMNRSRGKVL 600
DAIIQEKKSG RIPGIYGRLG DLGAIDEKYD VAISSCCHAL DYIVVDSIDI AQECVNFLKR 660
QNIGVATFIG LDKMAVWAKK MTEIQTPENT PRLFDLVKVK DEKIRQAFYF ALRDTLVADN 720
LDQATRVAYQ KDRRWRVVTL QGQIIEQSGT MTGGGSKVMK GRMGSSLVIE ISEEEVNKME 780
SQLQNDSKKA MQIQEQKVQL EERVVKLRHS EREMRNTLEK FTASIQRLIE QEEYLNVQVK 840
ELEANVLATA PDKKKQKLLE ENVSAFKTEY DAVAEKAGKV EAEVKRLHNT IVEINNHKLK 900
AQQDKLDKIN KQLDECASAI TKAQVAIKTA DRNLQKAQDS VLRTEKEIKD TEKEVDDLTA 960
ELKSLEDKAA EVVKNTNAAE ISKISLHPIE DNPIEEISVL SPEDLEAIKN PDSITNQIAL 1020
LEARCHEMKP NLGAIAEYKK KEELYLQRVA ELDKITYERD SFRQAYEDLR KQRLNEFMAG 1080
FYIITNKLKE NYQMLTLGGD AELELVDSLD PFSEGIMFSV RPPKKSWKKI FNLSGGEKTL 1140
SSLALVFALH HYKPTPLYFM DEIDAALDFK NVSIVAFYIY EQTKNAQFII ISLRNNMFEI 1200
SDRLIGIYKT YNITKSVAVN PKEIASKGLC 1230 
Gene Ontology
 GO:0000796; C:condensin complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; TAS:UniProtKB.
 GO:0005524; F:ATP binding; TAS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006310; P:DNA recombination; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0051383; P:kinetochore organization; IEA:Compara.
 GO:0010032; P:meiotic chromosome condensation; IEA:Compara.
 GO:0045132; P:meiotic chromosome segregation; IEA:Compara.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0007076; P:mitotic chromosome condensation; IDA:UniProtKB.
 GO:0007062; P:sister chromatid cohesion; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC.
 IPR024704; SMC.
 IPR010935; SMC_hinge. 
Pfam
 PF06470; SMC_hinge
 PF02463; SMC_N 
SMART
 SM00968; SMC_hinge 
PROSITE
  
PRINTS