CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011765
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable serine/threonine-protein kinase RTK1 
Protein Synonyms/Alias
 Ribosome biogenesis and tRNA synthetase-associated kinase 1 
Gene Name
 RTK1 
Gene Synonyms/Alias
 YDL025C; D2810 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
334FACKMFRKPHLNNEGubiquitination[1]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis. 
Sequence Annotation
 DOMAIN 302 575 Protein kinase.
 NP_BIND 308 316 ATP (By similarity).
 ACT_SITE 430 430 Proton acceptor (By similarity).
 BINDING 330 330 ATP (By similarity).
 MOD_RES 58 58 Phosphothreonine.
 MOD_RES 60 60 Phosphoserine.
 MOD_RES 216 216 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 620 AA 
Protein Sequence
MVKETPLHSS SSTSLSSLFR PTKLKNLSAK IFNGGGNQSY SKTDDVSRSS SRSSKKNTDS 60
DQEDQIKYNK PNDRRSTIGK SPQGNGALSK ESHVVASSTL TGISPTSAKK APIDYSPSRP 120
LPNNHNPVRT GHTVPHLPHS IHNPINYIHQ GSKDAFHHPH PVRSTAHSNI STVSSAKSDT 180
PSSNLSYQAH MHPVEILQKQ IEDKHFMDSQ ASTPGSVELQ HNSSSGSDDT SSRKKKSLRL 240
TRFFKKIHND YHDNHHHHHH HNRGSTPTKP KLNLNTNENI VESNGKALYE TDNPVELLEK 300
YGIPGRKLGE GASGSVSVVE RTDGKLFACK MFRKPHLNNE GTNQSQLANY SKKVTTEFCI 360
GSTLHHENIV ETLDMLTEGD TYLLVMEYAP YDFFNLVMSN LMTQDEVNCY FKQLCHGVNY 420
LHSMGLAHRD LKLDNCVVTK DGILKLIDFG SAVVFQYPYE DTIVKSHGIV GSDPYLAPEL 480
LKQTSYDPRV ADVWSIAIIF YCMVLKRFPW KAPKKSFNSF RLFTEEPEDE DDIVRGPNKI 540
LRLLPRHSRT IIGRMLALEP KQRVLMNDVV KDDWLVSVPS CEVDPTSGDL VEKPKNHKHH 600
LVTEEELNEL TKQHGNKDSN 620 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:SGD. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS